AI Article Synopsis
- The study evaluates the antifungal effectiveness of cisatracurium against fluconazole-resistant strains in both planktonic and biofilm forms.
- The research employed broth microdilution methods to assess antifungal activity, while flow cytometry and molecular docking were used to explore the mechanism of action.
- Findings indicate that cisatracurium alters mitochondrial function leading to cell death and effectively prevents biofilm formation as well as disrupts established biofilms, showcasing its potential as an antifungal agent.
Article Abstract
To evaluate the antifungal activity of cisatracurium against spp. resistant to fluconazole strains in planktonic and biofilm forms, in addition to determining its mechanism of action. Antifungal activity and pharmacological interactions were determined using broth microdilution methods and the mechanism of action was evaluated by flow cytometry and molecular docking. Cisatracurium presented antifungal activity against spp. planktonic cells due to alterations of mitochondrial transmembrane potential leading to cellular apoptosis in addition to interacting with important targets related to cellular respiration, membrane and cell wall evidenced by molecular docking. Furthermore, the drug both prevented biofilm formation and impaired mature biofilms. Cisatracurium exhibits potential antifungal activity against spp.
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| http://dx.doi.org/10.2217/fmb-2022-0224 | DOI Listing |
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