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| http://dx.doi.org/10.1021/acscentsci.3c00803 | DOI Listing |
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Paediatric strategy forum for medicinal product development in diffuse midline gliomas in children and adolescents ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration.
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ACCELERATE, Europe; Gustave Roussy Cancer Centre, Paris, France.
Fewer than 10 % of children with diffuse midline glioma (DMG) survive 2 years from diagnosis. Radiation therapy remains the cornerstone of treatment and there are no medicinal products with regulatory approval. Although the biology of DMG is better characterized, this has not yet translated into effective treatments.
View Article and Find Full Text PDFDevelopment and performance validation of an affordable and portable high-resolution darkfield polarization-sensitive multispectral imaging microscope for the assessment of radiation dermatitis and fibrosis.
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School of Optics and Photonics, Beijing Institute of Technology, Beijing 100081, China.
Radiation therapy (RT) is widely used for cancer treatment but is found with side effects of radiation dermatitis and fibrosis thereby calling for timely assessment. Nevertheless, current clinical assessment methods are found to be subjective, prone to bias, and accompanied by variability. There is, therefore, an unmet clinical need to explore a new assessment technique, ideally portable and affordable, making it accessible to less developed regions too.
View Article and Find Full Text PDFDo We Have Sufficient Evidence to Derive Innovative Approaches to Assessing Unmet Need, Delivering Education on Bladder and Bowel Continence Health, and Providing a Better Environment for Joint Decision-Making? ICI-RS 2024.
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Department of Medicine, College of Health Sciences, Faculty of Medicine & Dentistry, Division of Geriatric Medicine, Edmonton, Alberta, Canada.
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Comparison of carbon dioxide control during pressure controlled versus pressure-regulated volume controlled ventilation in children (CoCO2): protocol for a pilot digital randomised controlled trial in a quaternary paediatric intensive care unit.
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Department of Intensive Care and Neonatology and Children's Research Center, University of Zurich, University Children's Hospital Zürich, Zurich, Zurich, Switzerland.
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BioCirc Research Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, USA.
Background: Safe and effective pediatric blood pumps continue to lag far behind those developed for adults. To address this growing unmet clinical need, we are developing a hybrid, continuous-flow, magnetically levitated, pediatric total artificial heart (TAH). Our hybrid TAH design, the Dragon Heart (DH), integrates both an axial flow and centrifugal flow blood pump within a single, compact housing.
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