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http://dx.doi.org/10.3389/fnins.2023.1241069 | DOI Listing |
Int J Mol Sci
October 2023
Department of Medical, Surgical and Health Sciences, University of Trieste, 34149 Trieste, Italy.
The gut-liver-brain axis, a multifaceted network of communication, intricately connects the enteric, hepatic, and central nervous systems [...
View Article and Find Full Text PDFFront Neurosci
July 2023
International Research Center for Regenerative Medicine, Boao International Hospital, Qionghai, China.
Expert Rev Gastroenterol Hepatol
May 2015
Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.
The development of overt hepatic encephalopathy (HE) in a patient with cirrhosis confers a damning prognosis with a 1-year mortality approaching 64%. This complex neuropsychiatric syndrome arises as a consequence of a dysfunctional gut-liver-brain axis. HE has been largely neglected over the past 30 years, with the reliance on therapies aimed at lowering ammonia production or increasing metabolism following the seminal observation that the hepatic urea cycle is the major mammalian ammonia detoxification pathway and is key in the pathogenesis of HE.
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