A Bayesian Network (BN) is a probabilistic model that represents a set of variables using a directed acyclic graph (DAG). Current algorithms for learning BN structures from data focus on estimating the edges of a specific DAG, and often lead to many 'likely' network structures. In this paper, we lay the groundwork for an approach that focuses on learning global properties of the DAG rather than exact edges. This is done by defining the of a BN, which is shown to be related to the inverse-covariance matrix of the network. Spectral bounds are derived for the normalized inverse-covariance matrix, which are shown to be closely related to the maximum indegree of the associated BN.
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http://dx.doi.org/10.1016/j.laa.2023.06.003 | DOI Listing |
J Biomed Opt
January 2025
University of Ljubljana, Faculty of Mathematics and Physics, Ljubljana, Slovenia.
Significance: Machine learning models for the direct extraction of tissue parameters from hyperspectral images have been extensively researched recently, as they represent a faster alternative to the well-known iterative methods such as inverse Monte Carlo and inverse adding-doubling (IAD).
Aim: We aim to develop a Bayesian neural network model for robust prediction of physiological parameters from hyperspectral images.
Approach: We propose a two-component system for extracting physiological parameters from hyperspectral images.
Int J Clin Pharm
January 2025
Department of Pharmacology, The First People's Hospital of Yancheng, Yancheng, 224000, Jiangsu, China.
Background: Maribavir is a novel antiviral agent targeting cytomegalovirus through inhibition of the UL97 protein kinase, exhibiting a distinct mechanism of action. However, limited data are available on its safety profile post-marketing.
Aim: This study aimed to evaluate the adverse events (AEs) associated with maribavir using the Food and Drug Administration's Adverse Event Reporting System (FAERS), providing insights to inform clinical practice.
Sci Rep
January 2025
Department of Oncology, Senior Department of Respiratory and Critical Care Medicine, The Eighth Medical Center of Chinese PLA General Hospital, No.17 A Heishanhu Road, Haidian District, Beijing, 100853, China.
The ubiquitous use of rare earth elements (REEs) in modern living environments raised concern about their impact on human health. With the detrimental and beneficial effects of REEs reported by different studies, the genuine role of REEs in the human body remains a mystery. This study explored the association between REEs and genetic mutations in patients with lung adenocarcinoma (LUAD).
View Article and Find Full Text PDFJ Glob Antimicrob Resist
January 2025
Microbiology Unit, Clinical Pathology Department, Piacenza General Hospital, Piacenza, Italy; Medicine and Surgery Department, University of Parma, Parma, Italy.
Objectives: Infections by Carbapenem-Resistant Enterobacterales in hospitals represent a severe threat but little is known on outbreaks in rehabilitation wards caused by Klebsiella pneumoniae producing Klebsiella pneumoniae Carbapenemase (KPC-Kp). We report an outbreak by KPC-Kp, in a Neurorehabilitation Unit in Italy, analysed through Whole-Genome Sequencing (WGS) for transmission routes reconstruction to improve management of KPC-Kp infections in rehabilitation units.
Methods: We investigated cases and KPC-Kp isolates collected from February to October 2022 from hospital surveillance.
Epidemics
December 2024
Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, United States.
Over the last ten years, the US Centers for Disease Control and Prevention (CDC) has organized an annual influenza forecasting challenge with the motivation that accurate probabilistic forecasts could improve situational awareness and yield more effective public health actions. Starting with the 2021/22 influenza season, the forecasting targets for this challenge have been based on hospital admissions reported in the CDC's National Healthcare Safety Network (NHSN) surveillance system. Reporting of influenza hospital admissions through NHSN began within the last few years, and as such only a limited amount of historical data are available for this target signal.
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