[This corrects the article DOI: 10.1039/D3RA03413E.].
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| http://dx.doi.org/10.1039/d3ra90066e | DOI Listing |
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Paris Brain Institute, PARIS, France.
Background: Over-representation of several health conditions (such as diabetes, hearing loss, etc) have been identified up to 15 years before Alzheimer's Disease (AD) diagnosis through the study of electronic health records [1]. Mechanisms underlying these associations remain elusive. We propose to study the associations between these co-pathologies (proxied by genetic risk scores), and the physiological and clinical evolution of AD patients.
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Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: The intricate and heterogeneous phenotypes associated with neuropsychiatric symptoms (NPSs) encumber exploration of their role in the neuropathology and underlying biological mechanisms of Alzheimer's disease (AD) continuum.
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Unveiling the Oxidation Mechanisms of High-entropy Carbides Through Atomic-scale Dynamic Observation.
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January 2025
School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Understanding the behavior of high-entropy carbides (HECs) under oxygen-containing environments is of particular importance for their promising applications in structural components, catalysis, and energy-related fields. Herein, the structural evolution of (Ta, Ti, Cr, Nb)C (HEC-1) nanoparticles (NPs) is tracked in situ during the oxidation at the atomic scale by using an open-cell environmental aberration-corrected scanning transmission electron microscope. Three key stages are clearly discerned during the oxidation of HEC-1 NPs at the atomic level below 900 °C: i) increased amorphization of HEC-1 NPs from 300 to 500 °C due to the energetically favorable formation of carbon vacancies and substitution of carbon with oxygen atoms; ii) nucleation and subsequent growth of locally ordered nanocluster intermediates within the generated amorphous oxides from 500 to 800 °C; and iii) final one-step crystallization of non-equimolar MeO and MeO (Me = metallic elements, Ta, Ti, Cr, and Nb) high-entropy oxides above 800 °C, accompanied with the reduction in atomic defects.
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Xiamen Key Laboratory of Indoor Air and Health, Center for Excellence in Regional Atmospheric Environment, Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
Article Synopsis
- Antibiotic resistance genes (ARGs) from gut microbiota pose significant health risks and can be influenced by non-antibiotic factors like disease states, particularly in cases of cerebral ischemia-reperfusion injury (I/R) which is common in stroke patients.
- Changes in the gut antibiotic resistome during I/R show an increase in tetracycline ARGs while other types, like aminoglycoside and glycopeptide ARGs, decrease, suggesting a shift in microbial resistance profiles.
- The study identifies specific ARG hosts and pathways influenced by I/R, highlighting the increase in multidrug resistance genes and various biosynthetic processes in gut microbiota, providing potential targets for health interventions.
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