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| http://dx.doi.org/10.3389/fvets.2023.1245623 | DOI Listing |
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Coinfection with bacterial pathogens and genetic modification of PRRSV-2 for suppression of NF-κB and attenuation of proinflammatory responses.
Virology
March 2025
Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address:
Porcine reproductive and respiratory syndrome virus (PRRSV) infects pulmonary alveolar macrophages and induces inflammation in the respiratory system. In swine farms, coinfection with PRRSV and bacterial pathogens is common and can result in clinically complicated outcomes, including porcine respiratory disease complex. Coinfection can cause excessive expressions of proinflammatory mediators and may lead to cytokine-storm-like syndrome.
View Article and Find Full Text PDFCT- and MRI-based volumetry for Chiari-like malformation and syringomyelia in Pomeranians.
Front Vet Sci
February 2025
IVC Evidensia Small Animal Referral Hospital Arnhem, Neurology, Arnhem, Netherlands.
Introduction: Volumetric studies in relation to CM/SM have not been reported in Pomeranians. In this study, we aim to (1) report the intermodality agreement between CT- and MRI-based volumetric measurements of the skull and cervical spinal canal, and (2) assess for differences and associations between the volumetric measurements and CM/SM status.
Methods: Pomeranians were included that underwent CT and MRI studies during the period of February 2022-June 2024.
A non-randomized pilot study to test the feasibility of developing a frailty scale for pet cats.
Front Vet Sci
February 2025
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United States.
Introduction: Human frailty has long been studied and dozens of "frailty scales" have been developed, but equivalent research is more limited in cats. This pilot study aimed to determine the feasibility of recruiting and retaining veterinary practices and owners, collecting study data, and analyzing results about frailty in older cats.
Methods: Participating feline-exclusive practice veterinarians recruited cats aged 11-20 years, of either sex and of any breed.
Scientific highlights of the 8th world one health Congress, Cape Town, South Africa 2024.
One Health Outlook
March 2025
University of Veterinary Medicine, Hannover, 30559, Germany.
The 8th World One Health Congress took place in Cape Town, South Africa on 20-23 September 2024 to address all cross-sectoral and transdisciplinary aspects of the One Health paradigm, integrating human, animal, and environmental health. It brought together more than 1400 participants from 87 countries, and 400 speakers across 70 sessions. We summarize here the fourteen keynote lectures, which emphasized the need for a One Health approach to better integrate plant and agricultural health against food insecurity; the continuing challenges posed by antimicrobial resistance and emerging infectious threats; a paradigm shift towards health risk prevention; and approaches to further strengthen and expand the impact of the One Health movement.
View Article and Find Full Text PDFViral contamination in cell culture: analyzing the impact of Epstein Barr virus and Ovine Herpesvirus 2.
Front Microbiol
February 2025
Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom.
Cell culture techniques are increasingly favored over animal models due to rising costs, time constraints, and ethical concerns regarding animal use. These techniques serve critical roles in disease modeling, drug screening, drug discovery, and toxicity analysis. Notably, cell cultures facilitate primary virus isolation, infectivity assays, biochemical studies, and vaccine production.
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