AI Article Synopsis
- The study aimed to identify risk factors for new-onset atrial fibrillation (NOAF) in patients with advanced lung cancer by constructing and validating a nomogram model.
- Researchers analyzed data from 19,484 lung cancer patients, focusing on 1,089 who met the criteria after exclusion, using logistic regression and propensity score matching to find predictors of NOAF.
- Key independent risk factors identified included age, C-reactive protein levels, centric pulmonary carcinoma, and pericardial effusion, leading to a nomogram with good predictive accuracy for NOAF in this patient population.
Article Abstract
Objective: Risk factors of new-onset atrial fibrillation (NOAF) in advanced lung cancer patients are not well defined. We aim to construct and validate a nomogram model between NOAF and advanced lung cancer.
Methods: We retrospectively enrolled 19484 patients with Stage III-IV lung cancer undergoing first-line antitumor therapy in Shanghai Chest Hospital between January 2016 and December 2020 (15837 in training set, and 3647 in testing set). Patients with pre-existing AF, valvular heart disease, cardiomyopathy were excluded. Logistic regression analysis and propensity score matching (PSM) were performed to identify predictors of NOAF, and nomogram model was constructed and validated.
Results: A total of 1089 patients were included in this study (807 in the training set, and 282 in the testing set). Multivariate logistic regression analysis showed that age, c-reactive protein, centric pulmonary carcinoma, and pericardial effusion were independent risk factors, the last two of which were important independent risk factors as confirmed by PSM analysis. Nomogram included independent risk factors of age, c-reactive protein, centric pulmonary carcinoma, and pericardial effusion. The AUC was 0.716 (95% CI 0.661-0.770) and further evaluation of this model showed that the C-index was 0.716, while the bias-corrected C-index after internal validation was 0.748 in the training set. The calibration curves presented good concordance between the predicted and actual outcomes.
Conclusion: Centric pulmonary carcinoma and pericardial effusion were important independent risk factors for NOAF besides common ones in advanced lung cancer patients. Furthermore, the new nomogram model contributed to the prediction of NOAF.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374250 | PMC |
| http://dx.doi.org/10.3389/fonc.2023.1125592 | DOI Listing |
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