AI Article Synopsis
- - This study explores how elevated membrane potentials (MPs) in the prefrontal cortex (PFC) differ from those in the posterior parietal cortex (PPC), using experimental data and neural network models to understand these differences.
- - Researchers found that NMDA receptors play a significant role in increasing MP levels in the PFC, which affects overall neural network dynamics and cognitive functions in both brain areas.
- - The study emphasizes the importance of using modeling tools to examine how changes in synaptic properties can enhance cognitive functions by influencing the activities of neural populations in the PFC and PPC.
Article Abstract
In this study, we introduce the importance of elevated membrane potentials (MPs) in the prefrontal cortex (PFC) compared to that in the posterior parietal cortex (PPC), based on new observations of different MP levels in these areas. Through experimental data and spiking neural network modeling, we investigated a possible mechanism of the elevated membrane potential in the PFC and how these physiological differences affect neural network dynamics and cognitive functions in the PPC and PFC. Our findings indicate that NMDA receptors may be a main contributor to the elevated MP in the PFC region and highlight the potential of using a modeling toolkit to investigate the means by which changes in synaptic properties can affect neural dynamics and potentiate desirable cognitive functions through population activities in the corresponding brain regions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10372347 | PMC |
| http://dx.doi.org/10.3389/fncel.2023.1153970 | DOI Listing |
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