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Analyses of Adverse Drug Reactions to Fluoroquinolones in Spontaneous Reports Before and After the Referral and in Clinical Routine Cases.
Drugs R D
January 2025
Research Division, Federal Institute of Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.
Introduction: In November 2018, the European Medicines Agency (EMA) restricted the use of fluoroquinolones (used by mouth, injections or inhalation) in the context of a referral due to long-lasting and potentially irreversible adverse drug reactions (ADRs). Fluoroquinolones should no longer be used to treat mild or moderate bacterial infections unless other antibacterials cannot be used.
Objectives: The first aim of our study was to analyze whether in the period before compared with after the referral the characteristics of spontaneous ADR reports related to fluoroquinolones differed and whether specific ADRs were more frequently reported for fluoroquinolones compared with cotrimoxazole.
Evaluation of Cannabis Per Se Laws: A Semi-Mechanistic Pharmacometrics Model for Quantitative Characterization of THC and Metabolites in Oral Users.
J Clin Pharmacol
January 2025
Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA.
Recreational cannabis use has increased notably in the United States in the past decade, with a recent surge in oral consumption. This trend has raised concerns about driving under the influence. Current cannabis-impaired driving laws lack standardization, with some states implementing blood Δ9-tetrahydrocannabinol (THC) per se limits (1, 2, and 5 ng/mL).
View Article and Find Full Text PDFTrends in poisonings involving ketamine in the United States, 2019-2023.
Drug Alcohol Depend
January 2025
Rocky Mountain Poison & Drug Safety (RMPDS), A Division of Denver Health, Denver, CO, USA.
Background: Off-label prescribing of ketamine to treat psychiatric disorders has been increasing, as has recreational use and availability of illicit ketamine. It is important to examine trends in ketamine-related poisonings to inform public health efforts.
Methods: We examined data from poisonings (exposures) involving ketamine reported to Poison Centers in the US between 2019 and 2023 (n = 1519).
Horticultural activity in soil inoculated with Streptomyces rimosus improved depressive mood with altered electroencephalogram and serum metabolism in adults.
Sci Rep
January 2025
Department of Bio & Healing Convergence, Konkuk University, Seoul, 05029, Republic of Korea.
This study investigated the psychophysiological and metabolomic changes during horticultural activities involving the inhalation of volatile organic compounds (VOCs) in individuals experiencing depressive mood based on the presence or absence of the soil microbe Streptomyces rimosus, which emits VOCs. Thirty participants met the specific depression and anxiety criteria and engaged in horticultural activities using soil inoculated with S. rimosus (experimental group) or medium (control group).
View Article and Find Full Text PDFPhage therapy for extensively drug resistant infection: case report and evaluation of the distribution of phage and the impact on gut microbiome.
Front Med (Lausanne)
December 2024
National Clinical Research Centre for Infectious Diseases, Shenzhen Third People's Hospital and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.
Article Synopsis
- Bacteriophage therapy shows promise in treating infections caused by extensively drug-resistant bacteria (XDRAB), but its safety and impact on gut microbiota are still under scrutiny.
- During a study focused on an elderly female patient receiving inhaled phage therapy, bacteriophage DNA was detected in her blood primarily in the early days of treatment, while levels in sputum decreased significantly over time.
- Analysis of fecal samples revealed a substantial reduction in phage levels and significant changes in the gut microbiota composition, indicating that inhaled phages can enter the bloodstream and affect intestinal bacteria during treatment.
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