Double expressor lymphoma (DEL) is a subset of diffuse large B-cell lymphoma (DLBCL) characterized by the co-expression of MYC and BCL2 proteins with a poor prognosis. However, there are no standard criteria for evaluating the morphologic features of DEL. We aimed to analyze the prognostic value of the starry-sky pattern (SSP) and its correlation with clinicopathologic and genetic features in 153 DEL cases. The SSP was significantly associated with aggressive parameters, including c-MYC overexpression, CD5 expression, higher IPI, and age-adjusted IPI. In the univariate survival analyses, the presence of SSP was associated with unfavorable progression-free survival (PFS) (p = 0.040), and tended towards an adverse overall survival (OS) (p = 0.061). However, when c-MYC was overexpressed, SSP was significantly correlated with inferior OS (p = 0.019). In the multivariate survival analysis, SSP was also associated with poor PFS (p = 0.048). Additionally, next-generation sequencing data revealed SSP was significantly associated with the KMT2D mutation and had different genetic mutation profiles from non-SSP. In conclusion, SSP may represent morphologic characteristics of aggressiveness in DEL.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.humpath.2023.07.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical Manifestations.
Alzheimers Dement
December 2024
NYU Grossman School of Medicine, New York, NY, USA.
Background: We examined racial differences between measures of limbic white matter tracts and objective sleep parameters in cognitively unimpaired older-adults.
Method: This cross-sectional study included 170 community-dwelling cognitively unimpaired older-adults (mean±SD: age = 67.2±5.
Clinical Manifestations.
Alzheimers Dement
December 2024
University of Calgary, Calgary, AB, Canada.
Background: Mild behavioral impairment (MBI) is a syndrome that leverages neuropsychiatric symptoms that emerge in later-life, and which persist, to identify individuals at high-risk for incident dementia. Attendant with MBI are changes in quality of life (QoL), which can present concurrent with the onset of cognitive decline or even before. Obtaining information from participants and study partners can provide a broader overview of health and QoL.
View Article and Find Full Text PDFSurveillance for surgical site infections developed during hospital stay & after discharge: A multicentric study.
Indian J Med Res
November 2024
Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, India.
Background & objectives Surgical site infections (SSIs) are among the most prevalent healthcare-associated infections (HCAIs). They cause significant morbidity, leading to excess health expenditures and increased length of hospital stay. Despite a high population burden, data on post-discharge SSIs is lacking from low-and middle-income countries (LMICs).
View Article and Find Full Text PDFA framework of ecological security patterns in arid and semi-arid regions considering differences socioeconomic scenarios in ecological risk: Case of Loess Plateau, China.
J Environ Manage
December 2024
School of Surveying and Land Information Engineering, Henan Polytechnic University, Jiaozuo, Henan, 454003, China. Electronic address:
Understanding the establishment of ecological security patterns in arid and semi-arid regions is critical for global ecological risk prevention, control, and sustainable development. Nonetheless, there remains a relative deficiency in ecological risk assessment and construction of Ecological Security Patterns (ESP) in these areas, along with insufficient verification regarding the changes in ecological security patterns under diverse scenarios. This study employs Morphological Spatial Pattern Analysis (MSPA) to identify ecological sources and utilizes circuit theory alongside Minimum Cumulative Resistance (MCR) to delineate ecological corridors.
View Article and Find Full Text PDFOsWRKY49 on qAT5 positively regulates alkalinity tolerance at the germination stage in Oryza sativa L. ssp. japonica.
Theor Appl Genet
December 2024
Key Laboratory of Germplasm Enhancement, Physiology and Ecology of Food Crops in Cold Region, Ministry of Education, Northeast Agricultural University, Harbin, 150030, China.
Integrated genome-wide association study and linkage mapping revealed genetic basis of alkalinity tolerance during rice germination. The key gene OsWRKY49 was further verified in transgenic plants. With the widespread use of the rice direct seeding cultivation model, improving the tolerance of rice varieties to salinity-alkalinity at the germination stage has become increasingly important.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!