A novel Vestitain A from the ripe fruits of Roxb.

A new compound, vestitain A (), together with 11 known compounds were isolated from the ripe fruits of Roxb., among them compounds , were isolated from this plant for the first time. Their structures were elucidated and characterized by detailed spectroscopic analysis. Further, the isolated new compound was evaluated for its hypoglycemic effects . Our research showed that compound could decrease the fasting blood glucose (FBG) by approximately 36.31% in diabetic rats at the high dose (800 mg/kg). By the Morris Water Maze experiments, we found that compound had the effect of intervention on social behavior in diabetic rats, which might provide a reference basis for its development and utilization as a potential hypoglycemic drug.