AI Article Synopsis
- The study aimed to identify risk factors for the recurrence of laryngeal amyloidosis (LA) by analyzing clinical data from patients treated at a specific hospital over nearly 13 years.
- Out of 44 patients, most had localized LA in one area of the larynx, with the glottic region being the most affected; only a small percentage experienced recurrences post-surgery, typically around 24.5 months after treatment.
- Subglottic involvement was identified as a significant independent risk factor for recurrence, especially when it presented as diffuse deposition, leading to notably shorter recurrence times.
Article Abstract
Objective: To analyze the risk factors for recurrence of laryngeal amyloidosis (LA).
Methods: The clinical data of patients with LA admitted in the Otolaryngology Head and Neck Surgery Department of the Second Affiliated Hospital of Xi'an Jiaotong University from August 2009 to June 2022 were analyzed retrospectively; then, the risk factors for recurrence and their impacts on the recurrence time were also analyzed.
Results: Of the 44 patients with LA, the majority (38 cases, 86.4%) only involved one anatomical region and the others (6 cases, 13.6%) involved two laryngeal regions concurrently. Overall, the glottic region was the most commonly affected area (28 cases, 63.6%), followed by the supraglottic region (16 cases, 36.4%) and subglottic region (6 cases, 13.6%). In addition, all the lesions were categorized as isolated nodule (31.8%), submucosal localized deposition (52.3%), and submucosal diffuse deposition (15.9%) according to their morphologies under electronic laryngoscope. Finally, six patients (13.6%) had recurrence after operation with a median recurrence time of 24.5 months, and subglottic involvement was confirmed to be an independent risk factor for recurrence of LA by univariate and multivariate logistic regression analyses (P < 0.05). Meanwhile, the patients with subglottic involvement presented as submucosal diffuse deposition had a considerable shorter recurrence time (t = 5.759, P = 0.005).
Conclusion: The subglottic involvement is an independent risk factor for recurrence of LA.
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| http://dx.doi.org/10.1007/s00405-023-08150-2 | DOI Listing |
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