AI Article Synopsis

  • A novel magnetic nanozyme, FeO@MXene-Au, exhibits superior peroxidase-like activity compared to previous versions, allowing for easy separation and high recyclability.
  • This nanozyme, combined with glucose oxidase, creates an effective colorimetric biosensor that detects glucose by turning a colorless solution blue, with a detection limit of 0.11 mM.
  • A user-friendly agarose hydrogel platform integrates smartphone technology, enabling on-site and visual glucose detection, making it practical for real-world applications.

Article Abstract

A novel magnetic nanozyme FeO@MXene-Au nanocomposite, which possessed higher peroxidase-like activity than that of FeO nanoparticles and FeO@MXene nanocomposites, was developed. The outstanding magnetic properties of the nanozyme endowed it with the ability of simple and rapid separation, achieving great recyclability. Based on FeO@MXene-Au nanocomposites and glucose oxidase (Glu Ox), a highly selective colorimetric biosensor for glucose detection was developed. FeO@MXene-Au nanocomposites can catalyze HO produced from glucose catalyzed by glucose oxidase to ·OH and oxidize colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue oxidized TMB (oxTMB) with a significant absorbance at 652 nm. The linear range of glucose was 0-1.4 mM under optimal conditions, with a limit of detection (LOD) of 0.11 mM. Glucose in human whole blood was successfully detected with satisfactory recoveries. Furthermore, a facile agarose hydrogel detection platform was designed. With smartphone software, glucose detection can be realized by the agarose hydrogel platform, demonstrating the potential in on-site and visual detection of glucose.

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Source
http://dx.doi.org/10.1007/s00604-023-05900-1DOI Listing

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