Cases of Hemorrhagic Fever with Renal Syndrome in Russia during 2000-2022.

During 2000-2022, a total of 69 of Russia's 85 administrative regions reported 164,580 hemorrhagic fever with renal syndrome (HFRS) cases, with an annual average rate of 4.9 cases/100,000 population (10 popul.). European Russia reported 162,045 (98.5%) cases in 53/60 regions with 9.7 cases/10 popul. Asian Russia reported 2535 (1.5%) cases in 16/25 regions with 0.6 cases/10 popul. In the same period, Russia reported 668 (0.4%) fatal HFRS cases, and 4030 (2.4%) cases among children under the age of 14 years. Most HFRS cases occurred during autumn and winter. The incidence among rural residents was 6.7 per 10 popul., higher than the urban 4.4 per 10 popul.; however, among HFRS patients, rural and urban residents account for 35% and 65%, respectively. Six hantaviruses, causing HFRS of different clinical severity, were recognized as pathogens: Hantaan (HTNV) and Amur (AMUV) of species, Seoul (SEOV) of species, Puumala (PUUV) of species, and Kurkino (KURV) and Sochi (SOCV) of species, with the principal hosts , , , , , and , respectively. It was found that 97.7% of HFRS cases are caused by PUUV, therefore, this virus plays the main role in the HFRS morbidity structure in Russia.