Background: Accurate and fast image registration (IR) is critical during surgical interventions where the ultrasound (US) modality is used for image-guided intervention. Convolutional neural network (CNN)-based IR methods have resulted in applications that respond faster than traditional iterative IR methods. However, general-purpose processors are unable to operate at the maximum speed possible for real-time CNN algorithms. Due to its reconfigurable structure and low power consumption, the field programmable gate array (FPGA) has gained prominence for accelerating the inference phase of CNN applications.
Methods: This study proposes an FPGA-based ultrasound IR CNN (FUIR-CNN) to regress three rigid registration parameters from image pairs. To speed up the estimation process, the proposed design makes use of fixed-point data and parallel operations carried out by unrolling and pipelining techniques. Experiments were performed on three US datasets in real time using the xc7z020, and the xcku5p was also used during implementation.
Results: The FUIR-CNN produced results for the inference phase 139 times faster than the software-based network while retaining a negligible drop in regression performance of under 200 MHz clock frequency.
Conclusions: Comprehensive experimental results demonstrate that the proposed end-to-end FPGA-based accelerated CNN achieves a negligible loss, a high speed for registration parameters, less power when compared to the CPU, and the potential for real-time medical imaging.
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http://dx.doi.org/10.3390/s23146590 | DOI Listing |
Cancer Imaging
January 2025
Department of Surgery, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Background: Current diagnostic imaging modalities have limited ability to differentiate between malignant and benign pancreaticobiliary disease, and lack accuracy in detecting lymph node metastases. F-Prostate-Specific Membrane Antigen (PSMA) PET/CT is an imaging modality used for staging of prostate cancer, but has incidentally also identified PSMA-avid pancreatic lesions, histologically characterized as pancreatic ductal adenocarcinoma (PDAC). This phase I/II study aimed to assess the feasibility of F-PSMA PET/CT to detect PDAC.
View Article and Find Full Text PDFContemp Clin Trials
January 2025
Department of Neurology, University of California, Los Angeles, United States of America.
Background: Research suggest that mind-body movement programs have beneficial effects on cognitive outcomes for older adults with cognitive decline. However, few studies have directly compared specific approaches to mind-body movement or studied the impact of remote program delivery.
Methods: In a 3-arm randomized controlled trial (RCT) for older adults with cognitive impairment, we are comparing a multidomain mind-body program that emphasizes movement, body awareness, personal meaningfulness, and social connection, and a traditional Chinese mind-body exercise (Tai Chi) to a health and wellness education control condition.
J Am Acad Orthop Surg Glob Res Rev
January 2025
From the Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Tokyo (Dr. Kono, Dr. Taketomi, Dr. Kage, Dr. Inui, and Dr. Tanaka); the Department of Information Systems, Faculty of Engineering, Saitama Institute of Technology, Fukaya, Saitama (Dr. Yamazaki); the Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Suita, Osaka (Dr. Tamaki, and Dr. Tomita); the Department of Orthopedic Surgery, Saitama Medical University, Saitama Medical Center, Kawagoe, Saitama (Dr. Inui); and the Department of Health Science, Graduate School of Health Science, Morinomiya University of Medical Sciences, Suminoe, Osaka, Japan (Dr. Tomita).
Background: The effect of axial rotation between the femoral neck and ankle joint (total rotation [TR]) on normal knees is unknown. Therefore, this study aimed to investigate the TR effect on normal knee kinematics.
Methods: Volunteers were divided into groups large (L), intermediate (I), and small (S), using hierarchical cluster analysis based on TR in the standing position.
Heliyon
January 2025
BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia.
Breast-conserving surgery accompanied by adjuvant radiotherapy is the standard of care for patients with early-stage breast cancer. However, re-excision is reported in 20-30 % of cases, largely because of close or involved tumor margins in the specimen. Several intraoperative tumor margin assessment techniques have been proposed to overcome this issue, however, none have been widely adopted.
View Article and Find Full Text PDFOsteoarthr Cartil Open
March 2025
Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.
Objective: Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive hand OA.
Design: In total 163 participants with erosive hand OA, synovitis by ultrasound, and finger joint pain of 40-80 mm on a visual analogue scale (VAS) will be recruited from a rheumatology outpatient clinic.
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