AI Article Synopsis
- Metals are essential for all living organisms, and imbalances in metal levels can cause health issues due to disrupted homeostasis.
- Transition metals are increasingly used in pharmaceuticals for diagnostics and treatments due to their unique electronic properties that interact with biological molecules differently than organic ones.
- This review summarizes recent advancements in studying metal-drug complexes, focusing on various techniques for identifying protein targets and understanding how metallodrugs work, which could lead to the development of new drugs or enhancements to existing ones.
Article Abstract
Metals are indispensable for the life of all organisms, and their dysregulation leads to various disorders due to the disruption of their homeostasis. Nowadays, various transition metals are used in pharmaceutical products as diagnostic and therapeutic agents because their electronic structure allows them to adjust the properties of molecules differently from organic molecules. Therefore, interest in the study of metal-drug complexes from different aspects has been aroused, and numerous approaches have been developed to characterize, activate, deliver, and clarify molecular mechanisms. The integration of these different approaches, ranging from chemoproteomics to nanoparticle systems and various activation strategies, enables the understanding of the cellular responses to metal drugs, which may form the basis for the development of new drugs and/or the modification of currently used drugs. The purpose of this review is to briefly summarize the recent advances in this field by describing the technological platforms and their potential applications for identifying protein targets for discovering the mechanisms of action of metallodrugs and improving their efficiency during delivery.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385150 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics15071997 | DOI Listing |
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