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Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options. | LitMetric

Covalent Inhibitors for Neglected Diseases: An Exploration of Novel Therapeutic Options.

Pharmaceuticals (Basel)

Department of Pharmacy, School of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu Prestes, 580, Butantã, São Paulo 05508-000, Brazil.

Published: July 2023

AI Article Synopsis

Article Abstract

Neglected diseases, primarily found in tropical regions of the world, present a significant challenge for impoverished populations. Currently, there are 20 diseases considered neglected, which greatly impact the health of affected populations and result in difficult-to-control social and economic consequences. Unfortunately, for the majority of these diseases, there are few or no drugs available for patient treatment, and the few drugs that do exist often lack adequate safety and efficacy. As a result, there is a pressing need to discover and design new drugs to address these neglected diseases. This requires the identification of different targets and interactions to be studied. In recent years, there has been a growing focus on studying enzyme covalent inhibitors as a potential treatment for neglected diseases. In this review, we will explore examples of how these inhibitors have been used to target Human African Trypanosomiasis, Chagas disease, and Malaria, highlighting some of the most promising results so far. Ultimately, this review aims to inspire medicinal chemists to pursue the development of new drug candidates for these neglected diseases, and to encourage greater investment in research in this area.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385647PMC
http://dx.doi.org/10.3390/ph16071028DOI Listing

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