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Neglected Zoonotic Diseases: Advances in the Development of Cell-Penetrating and Antimicrobial Peptides against Leishmaniosis and Chagas Disease. | LitMetric

AI Article Synopsis

  • In 2020, the WHO launched a road map targeting the control and eradication of 20 neglected tropical diseases, focusing on conditions like leishmaniasis and Chagas disease.
  • The WHO has also been working on a Global Action Plan to combat Antimicrobial Resistance since 2015, highlighting the need for innovative treatment strategies in poor regions.
  • Natural peptide molecules (AMPs and CPPs) are emerging as promising alternatives to traditional therapies, as they show potential to enhance treatment effectiveness and reduce issues of toxicity and resistance in managing neglected zoonoses.

Article Abstract

In 2020, the WHO established the road map for neglected tropical diseases 2021-2030, which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas disease. In addition, since 2015, the WHO has been developing a Global Action Plan on Antimicrobial Resistance. In this context, the achievement of innovative strategies as an alternative to replace conventional therapies is a first-order socio-sanitary priority, especially regarding endemic zoonoses in poor regions, such as those caused by and spp. infections. In this scenario, it is worth highlighting a group of natural peptide molecules (AMPs and CPPs) that are promising strategies for improving therapeutic efficacy against these neglected zoonoses, as they avoid the development of toxicity and resistance of conventional treatments. This review presents the novelties of these peptide molecules and their ability to cross a whole system of cell membranes as well as stimulate host immune defenses or even serve as vectors of molecules. The efforts of the biotechnological sector will make it possible to overcome the limitations of antimicrobial peptides through encapsulation and functionalization methods to obtain approval for these treatments to be used in clinical programs for the eradication of leishmaniosis and Chagas disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383258PMC
http://dx.doi.org/10.3390/pathogens12070939DOI Listing

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