AI Article Synopsis
- Researchers discovered a new compound called panapophenanthrin from fungal cultures during their search for bioactive secondary metabolites.
- Two known compounds, panepophenanthrin and dihydrohypnophilin, were also isolated and their chemical structures were analyzed using advanced techniques like NMR and mass spectrometry.
- The compounds were tested for antimicrobial and cytotoxic effects, revealing that while two had moderate to weak antimicrobial activity, panapophenanthrin showed strong cytotoxic effects against certain mammalian cell lines.
Article Abstract
During the course of our search for biologically active secondary metabolites from fungal cultures, a new oligocyclic diterpenoidal derivative, panapophenanthrin (), was isolated from . In addition, two known metabolites, panepophenanthrin () and dihydrohypnophilin (), were also obtained. The chemical structures of the isolated compounds were elucidated based on extensive 1D and 2D NMR spectral analyses together with high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). The absolute configuration was determined through TDDFT-ECD calculations. All of the compounds were assessed for their antimicrobial and cytotoxic activities. Compounds and showed moderate to weak activities in the performed antimicrobial assays, while compound exhibited potent cytotoxic activity against the mammalian cell lines mouse fibroblast (L929) and human endocervical adenocarcinoma (KB3.1).
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385786 | PMC |
| http://dx.doi.org/10.3390/metabo13070848 | DOI Listing |
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