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Impact of Continuous Estroprogestin Treatment on Circulating Microparticle Levels in Deep Endometriosis Patients. | LitMetric

Impact of Continuous Estroprogestin Treatment on Circulating Microparticle Levels in Deep Endometriosis Patients.

Int J Mol Sci

Gynaecology Department, Clinic Institute of Gynaecology, Obstetrics and Neonatology (ICGON), Hospital Clinic of Barcelona, Universitat de Barcelona, 08007 Barcelona, Spain.

Published: July 2023

AI Article Synopsis

  • Research suggests that patients with deep-infiltrating endometriosis may have a hypercoagulable state, indicated by elevated inflammatory and coagulation markers, especially microparticles.
  • This study aimed to investigate how hormonal treatments, specifically combined oral contraceptives, affect these coagulation markers in patients with deep-infiltrating endometriosis.
  • Findings showed that patients on combined oral contraceptives had lower total microparticle levels, indicating reduced chronic inflammation, while their tissue factor levels were higher, hinting at the role of estrogen in influencing coagulation pathways.

Article Abstract

There has been increasing interest in the study of new pathogenic mechanisms in endometriosis (END), including the coagulation/fibrinolysis system and its link with inflammation and tissue remodeling. It has been suggested that END patients, especially with deep-infiltrating (DE) forms, could present a hypercoagulable state revealing higher levels of proinflammatory and procoagulant markers, such as total circulating microparticles (cMPs) and cMP-TF (tissue factor), released by cells in response to damage, activation, or apoptosis. However, no previous study has assessed the effect of END hormonal treatments on cMP and cMP-TF levels. Therefore, the aim of this study was to evaluate the impact of these treatments on cMP and cMP-TF levels in DE patients. Three groups were compared: DE patients receiving a continuous combined oral contraceptive regimen (CCOCR) (n = 41), DE patients without CCOCR (n = 45), and a control group (n = 43). cMP and cMP-TF levels were evaluated in platelet-free plasma. A significant decrease in the total cMP levels was found in the DE group with CCOCR versus the group without CCOCR, reflecting a higher chronic inflammatory status in DE patients that decreased with the treatment. cMP-TF levels were higher in DE patients receiving CCOCR versus those not receiving CCOCR, suggesting that treatments containing estrogens play a predominant role in suppressing the inhibitory pathway of TF.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380472PMC
http://dx.doi.org/10.3390/ijms241411802DOI Listing

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