Polyoxometalates have emerged as promising bactericidal agents. In the current study, the bactericidal activity of polyoxometalate K[PMoO] against () O157:H7 and its possible underlying mechanisms were explored. The obtained results demonstrated that K[PMoO] could effectively kill O157:H7 at millimolar levels. Moreover, K[PMoO] treatment also induced significant increases in recA protein expression and further triggered characteristic apoptosis-like bacterial death events such as DNA fragmentation and phosphatidylserine exposure. In conclusion, polyoxometalate K[PMoO] possesses a desirable antibacterial activity, and induction of bacterial apoptosis-like death might be involved in its underlying bactericidal mechanisms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380553 | PMC |
| http://dx.doi.org/10.3390/ijms241411469 | DOI Listing |
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- CUST-961 demonstrated significantly higher proton conductivity than CUST-962, attributed to its higher number of uncoordinated carboxylic acid groups that enhance hydrogen bonding and proton sources, highlighting a novel approach to creating proton conductive materials.*
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