K channels are involved in many critical functions in lung physiology. Recently, the family of Ca-activated K channels (K) has received more attention, and a massive amount of effort has been devoted to developing selective medications targeting these channels. Within the family of K channels, three small-conductance Ca-activated K (K2) channel subtypes, together with the intermediate-conductance K3.1 channel, are voltage-independent K channels, and they mediate Ca-induced membrane hyperpolarization. Many K2 channel members are involved in crucial roles in physiological and pathological systems throughout the body. In this article, different subtypes of K2 and K3.1 channels and their functions in respiratory diseases are discussed. Additionally, the pharmacology of the K2 and K3.1 channels and the link between these channels and respiratory ciliary regulations will be explained in more detail. In the future, specific modulators for small or intermediate Ca-activated K channels may offer a unique therapeutic opportunity to treat muco-obstructive lung diseases.
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| http://dx.doi.org/10.3390/biomedicines11071780 | DOI Listing |
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