AI Article Synopsis
- Bullous pemphigoid (BP) is an autoimmune skin disease with a rising incidence, marked by blister formation due to specific autoantibodies targeting skin proteins.
- The condition involves not only autoantibodies but also the body's inflammatory response, highlighting the role of various immune cells.
- This review focuses on the contributions of eosinophils, basophils, and neutrophils in the development and progression of BP.
Article Abstract
Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230. Although autoantibodies trigger inflammatory cascades that lead to blister formation, effector cells and cell-mediated autoimmunity must also be considered as important factors in the pathogenesis of BP. The aim of this review is to outline the current knowledge on the role of eosinophils, basophils, and neutrophils in BP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377006 | PMC |
| http://dx.doi.org/10.3390/biom13071019 | DOI Listing |
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