AI Article Synopsis
- The velocity time integral (VTI) is a Doppler ultrasound measurement used to evaluate blood flow, specifically looking at the middle cerebral artery (MCA) in fetuses affected by maternal alloimmunization.
- This study analyzed 255 Doppler examinations across different gestational weeks and found that VTI increases as pregnancy progresses, with significant differences in values when comparing fetuses with suspected anemia to those without.
- The findings suggest that higher VTI in fetuses may indicate increased blood flow to the brain, potentially serving as a new marker for detecting fetal anemia.
Article Abstract
The velocity time integral (VTI) is a clinical Doppler ultrasound measurement of blood flow, measured by the area under the wave curve and equivalent to the distance traveled by the blood. This retrospective study assessed the middle cerebral artery (MCA) VTI of fetuses in pregnancies complicated by maternal alloimmunization. Doppler indices of the MCA were retrieved from electronic medical records. Systolic deceleration-diastolic time, systolic acceleration time, VTI, and peak systolic velocity (PSV) were measured at 16-40 weeks gestation. Cases with PSV indicating fetal anemia (cutoff 1.5 MoM) and normal PSV were compared. The study included 255 Doppler ultrasound examinations. Of these, 41 were at 16-24 weeks (group A), 100 were at 25-32 weeks (group B), and 114 were at 33-40 weeks (group C). VTI increased throughout gestation (5.5 cm, 8.6 cm, and 12.1 cm in groups A, B, and C, respectively, = 0.003). VTI was higher in waveforms calculated to have MCA-PSV ≥ 1.5 MoM compared to those with MCA-PSV < 1.5 MoM (9.1 cm vs. 14.1 cm, respectively, < 0.001), as was VTI/s (22.04 cm/s vs. 33.75 cm/s, respectively; < 0.001). The results indicate that the MCA VTI increases significantly among fetuses with suspected anemia, indicating higher perfusion of hemodiluted blood to the brain. This feasible measurement might provide a novel additional marker for the development of fetal anemia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377850 | PMC |
| http://dx.doi.org/10.3390/children10071090 | DOI Listing |
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