A Role of PI3K/Akt Signaling in Oocyte Maturation and Early Embryo Development.

Cells

Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 277 21 Libechov, Czech Republic.

Published: July 2023

AI Article Synopsis

  • Akt (protein kinase B) is crucial in the PI3K/Akt signaling pathway, which controls cell survival, metabolism, and growth.
  • It phosphorylates various substrates that manage processes like nuclear envelope breakdown, chromosome segregation, and cytokinesis.
  • The review also discusses Akt's role in mRNA translation regulation, particularly in early development stages such as oogenesis and embryo formation.

Article Abstract

A serine/threonine-specific protein kinase B (PKB), also known as Akt, is a key factor in the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway that regulates cell survival, metabolism and proliferation. Akt phosphorylates many downstream specific substrates, which subsequently control the nuclear envelope breakdown (NEBD), centrosome maturation, spindle assembly, chromosome segregation, and cytokinesis. In vertebrates, Akt is also an important player during oogenesis and preimplantation development. In the signaling pathways regulating mRNA translation, Akt is involved in the control of mammalian target of rapamycin complex 1 (mTORC1) and thereby regulates the activity of a translational repressor, the eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1). In this review, we summarize the functions of Akt in mitosis, meiosis and early embryonic development. Additionally, the role of Akt in the regulation of mRNA translation is addressed with respect to the significance of this process during early development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378481PMC
http://dx.doi.org/10.3390/cells12141830DOI Listing

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