AI Article Synopsis
- The emergence of strains producing ESBL and KPC enzymes poses a major public health challenge due to their ability to promote antibiotic resistance and create biofilms that prolong infections in healthcare settings.
- The study isolated 45 strains from human infections and found a significant 73% rate of multidrug resistance, particularly to antibiotics like ampicillin and cefotaxime, while tetracycline and amikacin were the most effective.
- Of the strains tested, 80% were capable of biofilm production; however, most ESBL and KPC producers were weak biofilm producers, indicating no strong link between biofilm strength and the presence of these resistance enzymes.
Article Abstract
The appearance of strains producing extended-spectrum β-lactamase (ESBL), and carbapenemase (KPC) has turned into a significant public health issue. ESBL- and KPC-producing 's ability to form biofilms is a significant concern as it can promote the spread of antibiotic resistance and prolong infections in healthcare facilities. A total of 45 strains were isolated from human infections. Antibiograms were performed for 17 antibiotics, ESBL production was tested by Etest ESBL PM/PML, a rapid test was used to detect KPC carbapenemases, and resistance genes were detected by PCR. Biofilm production was detected by the microtiter plate method. A total of 73% of multidrug resistance was found, with the highest resistance rates to ampicillin, trimethoprim-sulfamethoxazole, cefotaxime, amoxicillin-clavulanic acid, and aztreonam. Simultaneously, the most effective antibiotics were tetracycline and amikacin. , , , , , , , , , , , , , , , , and genes were detected. Biofilm production showed that 80% of strains were biofilm producers. Most ESBL- and KPC-producing isolates were weak biofilm producers (40.0% and 60.0%, respectively). There was no correlation between the ability to form stronger biofilms and the presence of ESBL and KPC enzymes in isolates.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376346 | PMC |
| http://dx.doi.org/10.3390/antibiotics12071143 | DOI Listing |
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