Diarrhea in piglets is one of the most common diseases leading to high mortality and, as a result, to economic losses. Shotgun metagenomic sequencing was performed on the DNBSEQ-G50, MGI system to study the role of the fecal microbiome in the development of diarrhea in newborn piglets. Analysis of the study data showed that the composition of the fecal microbiome at the level of bacteria and fungi did not differ in piglets with diarrhea from the healthy group. Bacteria belonging to the phyla , , , , and were the most abundant. However, a higher level of bacterial alpha diversity was observed in the group of piglets with diarrhea, which may be due to dysbacteriosis and inflammation. The study of the virome showed the difference between the two types of phages: B40-8 prevailed in diseased piglets, while virus BP4 was found in greater numbers in healthy piglets. The results of our study suggest that the association between the fecal microbiome and susceptibility to diarrhea in suckling piglets may have been previously overestimated.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376196 | PMC |
| http://dx.doi.org/10.3390/ani13142303 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Alcohol-induced gut microbial reorganization and associated overproduction of phenylacetylglutamine promotes cardiovascular disease.
Nat Commun
December 2024
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
The mechanism(s) underlying gut microbial metabolite (GMM) contribution towards alcohol-mediated cardiovascular disease (CVD) is unknown. Herein we observe elevation in circulating phenylacetylglutamine (PAGln), a known CVD-associated GMM, in individuals living with alcohol use disorder. In a male murine binge-on-chronic alcohol model, we confirm gut microbial reorganization, elevation in PAGln levels, and the presence of cardiovascular pathophysiology.
View Article and Find Full Text PDFLysate of prevents severe forms of experimental autoimmune encephalomyelitis by modulating the priming of T cell response.
Front Immunol
December 2024
Laboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
The gut microbiota influences the reactivity of the immune system, and has emerged as an anti-inflammatory commensal. Here, we investigated whether its lysate could prevent severe forms of neuroinflammation in experimental autoimmune encephalomyelitis (EAE) in mice and how this preventive strategy affects the gut microbiota and immune response. Lysate of anaerobically cultured (Pd lysate) was orally administered to C57BL/6 mice in four weekly doses.
View Article and Find Full Text PDFWhole-genome sequencing and genomic analysis of four strains newly isolated from human feces.
Front Microbiol
December 2024
West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
Background: Numerous studies have demonstrated that is closely associated with human health. These bacteria colonize the mucus layer of the gastrointestinal tract and utilize mucin as their sole source of carbon and nitrogen. spp.
View Article and Find Full Text PDFInter-year consistencies and discrepancies on intestinal microbiota for overwintering relict gulls: correlations with food composition and implications for environmental adaptation.
Front Microbiol
December 2024
College of Life Sciences, Tianjin Normal University, Tianjin, China.
The gut microbiota of migratory birds is influenced by their food choices, and exploring the potential relationship between diet composition and gut microbiota can help better protect related species. By integrating non-invasive sampling techniques, high-throughput sequencing technology, and microscopic examination technology, this study presents the first evidence on diet composition during overwintering periods as well as the potential relationship between diet composition and gut microbiota in wild relict gulls (). Thirty-five fecal samples from two consecutive overwintering periods (2021 and 2022 overwintering periods) in Tianjin coastal wetland were used to investigate inter-year consistencies and discrepancies on diet composition and gut microbiota in wild It was found that the common dominant phyla of both 2021 and 2022 group included Firmicutes, Proteobacteria, Chloroflexi and Actinobacteriota.
View Article and Find Full Text PDFThe changes of intestinal flora and metabolites in atopic dermatitis mice.
Front Microbiol
December 2024
Yunnan Botanee Bio-Technology Group Co., Ltd., Kunming, China.
Introduction: Atopic dermatitis (AD) is an allergic disease caused by various factors that can affect an individual's appearance and cause psychological stress. Therefore, it is necessary to investigate the underlying mechanisms and develop effective treatment strategies. The gut microbiota and bacterial metabolism play crucial roles in human diseases.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!