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Single-tablet-scale direct-compression: An on-demand manufacturing route for personalized tablets. | LitMetric

Single-tablet-scale direct-compression: An on-demand manufacturing route for personalized tablets.

Int J Pharm

Institute for Process- and Particle Engineering, Graz University of Technology, Inffeldgasse 13, A-8010 Graz, Austria; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, A-8010 Graz, Austria. Electronic address:

Published: August 2023

AI Article Synopsis

Article Abstract

Today's pharmaceutical industry is facing various challenges. Two of them are issues with supply chain security and the increasing demand for personalized medicine. Both can be addressed by increasing flexibility and a more decentralized approach to pharmaceutical manufacturing. In this study, we present a setup that provides flexibility in terms of supplied raw materials and the product, i.e., a direct-compression setup for personalized tablets operating at a single-tablet-scale. The performance of the implemented single-tablet-scale technology for dosing and mixing was investigated. In addition, an analysis of the critical quality attributes (CQAs) of immediate release ibuprofen and loratadine tablets was performed. The developed dosing device achieved acceptance rates of > 90 % for doses ≥ 20 mg for various pharmaceutical powders. Regarding the vibratory mixing process, a dependency of the performance on the applied frequencies and acceleration was observed, with 100 Hz and ∼ 90 G performing best, yet still exhibiting varying mixing efficacies depending on the granular system. The tablets produced met U.S. Pharmacopeia requirements regarding mechanical stability and dissolution characteristics. Given these results, we consider the developed setup a proof of concept of a tool to provide personalized tablets to patients while minimizing the dependency on complex supply chains.

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Source
http://dx.doi.org/10.1016/j.ijpharm.2023.123274DOI Listing

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