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C adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke. | LitMetric

C adduct with L-arginine as a promising nanomaterial for treating cerebral ischemic stroke.

Nanomedicine

Pavlov First Saint Petersburg State Medical University, 6-8 L'va Tolstogo Str., Saint Petersburg, 197022, Russia; Institute of Chemistry, Saint Petersburg State University, 26 Universitetskii Pr., Saint Petersburg, 198504, Russia; A. M. Granov Russian Research Centre for Radiology and Surgical Technologies, 70 Leningradskaia Str., Saint Petersburg, 197758, Russia. Electronic address:

Published: September 2023

AI Article Synopsis

Article Abstract

The work aimed to investigate the biocompatibility and biological activity of the water-soluble fullerene adduct C-Arg. It was found that the material is haemocompatible, is not cyto- and genotoxic, possesses pronounced antioxidant activity. Additionally, this paper outlines the direction of application of water-soluble fullerene adducts in the creation of neuroprotectors. It has been suggested that a putative mechanism of the protective action of the C-Arg adduct is associated with its antioxidant properties, the ability to penetrate the blood-brain barrier, and release nitrogen monoxide as a result of the catabolism of L-arginine residues, which promote vascular relaxation. The action of the C-Arg adduct was compared with the action of such an antioxidant as Edaravone, which is approved in Japan for the treatment of ischemic and haemorrhagic strokes.

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Source
http://dx.doi.org/10.1016/j.nano.2023.102698DOI Listing

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