Automated and semi-automated packed sorbent solid phase (micro) extraction methods for extraction of organic and inorganic pollutants.

In this study, the packed sorbent solid phase (micro) extraction methods from manual to automated modes are reviewed. The automatic methods have several remarkable advantages such as high sample throughput, reproducibility, sensitivity, and extraction efficiency. These methods include solid-phase extraction, pipette tip micro-solid phase extraction, microextraction by packed sorbent, in-tip solid phase microextraction, in-tube solid phase microextraction, lab-on-a-chip, and lab-on-a-valve. The recent application of these methods for the extraction of organic and inorganic compounds are discussed. Also, the combination of novel technologies (3D printing and robotic platforms) with the (semi)automated methods are investigated as the future trend.