Base-Catalyzed One-Pot Synthesis of 2,3,6-Substituted Pyridines.

J Org Chem

School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, P.R. China.

Published: August 2023

A three-component reaction catalyzed by base was established, which mainly consisted of ynals, isocyanates, amines and alcohols. This strategy provides a wide range of substrates and represents a simple process for the preparation of different pyridine derivatives in good yields with high regioselectivities.

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Source
http://dx.doi.org/10.1021/acs.joc.3c00375DOI Listing

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