A general strategy for the synthesis of 2,4'-disubstituted glycoluril enantiomers on a multigram scale using orthogonal protection is reported. The use of these glycolurils is demonstrated in the synthesis of enantiomerically pure bambus[6]uril macrocycles. Moreover, the deprotection of ()-1-phenylethyl substituents on the macrocycle was achieved, opening access to various chiral bambus[6]urils post-macrocyclization modification strategy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442914 | PMC |
| http://dx.doi.org/10.1021/acs.joc.3c00667 | DOI Listing |
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