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Nephrotic syndrome following COVID-19 vaccination: a systematic review. | LitMetric

AI Article Synopsis

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused significant health issues, and while vaccines are effective, there are reports of adverse effects, including nephrotic syndrome.
  • A literature review analyzed 21 articles and compiled data from 74 patients to better understand the incidence and management of this condition following vaccination.
  • Nephrotic syndrome post-vaccination is linked to the activation of specific receptors, and treatment generally involves corticosteroids, emphasizing the need for further research to improve early diagnosis and kidney protection.

Article Abstract

Background: Severe acute respiratory syndrome coronavirus 2 infection has caused significant morbidity and mortality. Vaccines produced against this virus have proven highly effective. However, adverse events following vaccination have also been reported. One of them is nephrotic syndrome, that can be associated with different pathologic pictures. This review aims to provide a wider understanding of incidence, etiopathogenesis, and management of nephrotic syndrome following vaccination against SARS-CoV-2.

Methods And Results: A literature search was undertaken using appropriate keywords in various databases like PubMed, Google Scholar, Europe PMC, and Science Direct. Twenty-one articles were included following qualitative assessment. Data of 74 patients from these articles were included.

Discussion: The pathogenesis of nephrotic syndrome following COVID vaccination has been widely attributed to the activation of angiotensin-converting enzyme-2 receptors, leading to podocyte effacement. Relapses have also been reported in patients with prior history of nephrotic syndrome following COVID-19 vaccination. A renal biopsy is necessary to identify the histopathological picture. Management of COVID-19 vaccine-induced nephrotic syndrome was mainly reported as successfully attainable with corticosteroids and supportive management.

Conclusion: Further investigations will help in establishing an early diagnosis and salvaging kidney function.

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Source
http://dx.doi.org/10.1007/s40620-023-01710-zDOI Listing

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