AI Article Synopsis
- This study examined whether preoperative MRI can help reduce positive margins in breast-conserving surgery (BCS) for breast cancer patients.
- In a trial with 631 participants, preoperative MRI was used in about 30% of cases, and while those patients showed a slightly lower rate of positive margins, the difference wasn't statistically significant.
- The conclusion indicated that factors like patient age and tumor size were more influential on margin status than the use of preoperative MRI.
Article Abstract
Background: Breast-conserving surgery (BCS) is a mainstay for breast cancer management, and obtaining negative margins is critical. Some have advocated for the use of preoperative magnetic resonance imaging (MRI) in reducing positive margins after BCS. We sought to determine whether preoperative MRI was associated with reduced positive margins.
Patients And Methods: The SHAVE/SHAVE2 trials were multicenter trials in ten US centers with patients with stage 0-3 breast cancer undergoing BCS. Use of preoperative MRI was at the discretion of the surgeon. We evaluated whether or not preoperative MRI was associated with margin status prior to randomization regarding resection of cavity with shave margins.
Results: A total of 631 patients participated. Median age was 64 (range 29-94) years, with a median tumor size of 1.3 cm (range 0.1-9.3 cm). Patient factors included 26.1% of patients (165) had palpable tumors, and 6.5% (41) received neoadjuvant chemotherapy. Tumor factors were notable for invasive lobular histology in 7.0% (44) and extensive intraductal component (EIC) in 32.8% (207). A preoperative MRI was performed in 193 (30.6%) patients. Those who underwent preoperative MRI were less likely to have a positive margin (31.1% versus 38.8%), although this difference was not statistically significant (p = 0.073). On multivariate analysis, controlling for patient and tumor factors, utilization of preoperative MRI was not a significant factor in predicting margin status (p = 0.110). Rather, age (p = 0.032) and tumor size (p = 0.040) were the only factors associated with margin status.
Conclusion: These data suggest that preoperative MRI is not associated margin status; rather, patient age and tumor size are the associated factors.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1245/s10434-023-13884-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence and Risk Factors for Medial Meniscus Ramp Lesions in the Setting of Pediatric Anterior Cruciate Ligament Injuries: A Systematic Review and Meta-analysis.
J Pediatr Orthop
January 2025
Department of Pediatric Orthopedic Surgery, Hospital for Special Surgery, New York, NY.
Background: Medial meniscus ramp lesions (MMRLs) are commonly associated with anterior cruciate ligament (ACL) injuries and may increase the risk of graft failure after ACL reconstruction (ACLR) if undiagnosed or left untreated. Although MMRLs have been extensively reported in adults, there are limited studies describing them in pediatric patients undergoing ACLR. The purpose of this study was to perform a systematic review and meta-analysis to determine the pooled prevalence of and risk factors for MMRLs in pediatric patients with ACL injuries.
View Article and Find Full Text PDFAim: Successful deep brain stimulation (DBS) requires precise electrode placement. However, brain shift from loss of cerebrospinal fluid or pneumocephalus still affects aim accuracy. Multidetector computed tomography (MDCT) provides absolute spatial sensitivity, and intraoperative cone-beam computed tomography (iCBCT) has become increasingly used in DBS procedures.
View Article and Find Full Text PDFRetrospective Evaluation Of Radiological And Clinical Postoperative Findings Of Patients Who Had Endoscopic Lumbar Discectomy.
Turk Neurosurg
February 2024
SBÜ Gaziosmanpaşa Eğitim ve Araştırma Hastanesi.
Aim: Minimally-invasive spinal surgery is increasingly being adopted worldwide. In this study, we evaluated the postoperative magnetic resonance imaging (MRI) findings and clinical outcomes of patients who underwent full endoscopic lumbar disk surgery.
Methods: Preoperative and postoperative 3rd and 6th month MRI features, visual analog scale (VAS) score, Oswestry Disability Index (ODI), and clinical features of patients who underwent percutaneous endoscopic lumbar discectomy between August 2009 and January 2012 were retrospectively analyzed.
Outcomes of Coronary Artery Bypass Grafting in Patients With Impaired Left Ventricular Function and the Role of Preoperative Myocardial Viability.
Cureus
December 2024
Cardiovascular Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.
Background Coronary artery bypass grafting (CABG) improves outcomes in patients with ischemic left ventricular (LV) dysfunction, but accurate patient selection remains critical. Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging aids in assessing myocardial viability, a key predictor of surgical outcomes. This study aimed to evaluate the impact of myocardial viability on postoperative outcomes in patients undergoing CABG.
View Article and Find Full Text PDFThe Superior Glenoid Humeral Ligament's Role in Superior Labrum Anterior-Posterior Lesions and Subtype Classification Based on Arthroscopic Views: A Multicenter, Retrospective Study.
Orthop J Sports Med
January 2025
Department of Orthopaedic Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Background: Superior labrum anterior-posterior (SLAP) lesions are common shoulder injuries. The 10-type classification system has been widely used to diagnose SLAP lesions since it was proposed. However, growing evidence from arthroscopic studies indicates the existence of many SLAP lesions, especially those associated with superior glenoid humeral ligament (SGHL) injuries, that were not included in the initial classification.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!