A hybrid data-driven/finite volume method for 2D and 3D thermal convective flows is introduced. The approach relies on a single-step loss, convolutional neural network that is active only in the near-wall region of the flow. We demonstrate that the method significantly reduces errors in the prediction of the heat flux over the long-time horizon and increases pointwise accuracy in coarse simulations, when compared to direct computations on the same grids with and without a traditional subgrid model. We trace the success of our machine learning model to the choice of the training procedure, incorporating both the temporal flow development and distributional bias.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1140/epje/s10189-023-00302-w | DOI Listing |
RSC Adv
January 2025
Innovative Informatica Technologies Hyderabad Telangana India.
Non-Small Cell Lung Cancer (NSCLC) is a formidable global health challenge, responsible for the majority of cancer-related deaths worldwide. The Platelet-Derived Growth Factor Receptor (PDGFR) has emerged as a promising therapeutic target in NSCLC, given its crucial involvement in cell growth, proliferation, angiogenesis, and tumor progression. Among PDGFR inhibitors, avapritinib has garnered attention due to its selective activity against mutant forms of PDGFR, particularly PDGFRA D842V and KIT exon 17 D816V, linked to resistance against conventional tyrosine kinase inhibitors.
View Article and Find Full Text PDFChina CDC Wkly
December 2024
Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an City, Shaanxi Province, China.
China faces a critical public health challenge with obesity rates exceeding 50% among adults and 20% among children. In response, the National Health Commission launched a comprehensive three-year "Year of Weight Management" initiative in March 2024, further emphasized by the 36th Patriotic Health Month's theme "Healthy Towns - Healthy Weight" in April 2024. These initiatives underscore the urgent necessity for implementing comprehensive strategies to combat obesity and its associated non-communicable diseases.
View Article and Find Full Text PDFPractical identifiability is a critical concern in data-driven modeling of mathematical systems. In this paper, we propose a novel framework for practical identifiability analysis to evaluate parameter identifiability in mathematical models of biological systems. Starting with a rigorous mathematical definition of practical identifiability, we demonstrate its equivalence to the invertibility of the Fisher Information Matrix.
View Article and Find Full Text PDFClin Transl Sci
January 2025
Global Biometrics and Data Management, Pfizer Research and Development, New York, New York, USA.
The pharmaceutical industry constantly strives to improve drug development processes to reduce costs, increase efficiencies, and enhance therapeutic outcomes for patients. Model-Informed Drug Development (MIDD) uses mathematical models to simulate intricate processes involved in drug absorption, distribution, metabolism, and excretion, as well as pharmacokinetics and pharmacodynamics. Artificial intelligence (AI), encompassing techniques such as machine learning, deep learning, and Generative AI, offers powerful tools and algorithms to efficiently identify meaningful patterns, correlations, and drug-target interactions from big data, enabling more accurate predictions and novel hypothesis generation.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Department of Structures for Engineering and Architecture, University of Naples Federico II, Via Claudio 21, 80125 Naples, Italy.
The growing importance of state assessments in civil engineering has led to intensive research into the development of damage identification methods based on vibrations. Natural frequencies and modal shapes have garnered great interest because modal parameters are invariant of structure. Moreover, thanks to the global nature of modal parameters, their variations are not limited to the location of the damage.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!