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HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease.

Redox Biol

December 2024

Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon, 16419, Republic of Korea; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:

The dynamic equilibrium between acetylation and deacetylation is vital for cellular homeostasis. Parkinson's disease (PD), a neurodegenerative disorder marked by α-synuclein (α-syn) accumulation and dopaminergic neuron loss in the substantia nigra, is associated with a disruption of this balance. Therefore, correcting this imbalance with histone deacetylase (HDAC) inhibitors represents a promising treatment strategy for PD.

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  • - The study investigates the use of BET-loaded liposomal nanocarriers (LPN) as a potential new treatment for Alzheimer’s disease (AD) due to the low effectiveness of betanin (BET) from previous research.
  • - In an experiment with 48 male Wistar rats, those treated with BET LPN showed significant improvements in memory and reduced brain degeneration compared to rats receiving other forms of BET or a control treatment.
  • - BET LPN treatment not only improved cognitive function but also targeted specific biomarkers and pathways associated with AD, suggesting that it may be a more effective method than traditional oral BET for combating the disease.
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  • The research focuses on developing nanocarriers that mimic cell membranes to enhance the delivery of asparaginase, an enzyme used in cancer treatment.
  • These nanocarriers incorporate a scaffold targeted to CD44, a receptor often overexpressed in cancer cells, enabling more effective drug delivery.
  • The study demonstrates that these engineered nanocarriers can improve therapeutic outcomes by increasing the concentration of asparaginase at tumor sites while reducing side effects.
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  • The text serves to address an error or issue related to a previously published article identified by its DOI (Digital Object Identifier) number.
  • It likely provides clarification or correction on findings, methods, or conclusions presented in the original article.
  • The DOI mentioned indicates that the correction is a formal update in the academic record, ensuring that readers can access accurate information.
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