Objective: There are regional disparities in endovascular thrombectomy, and problems with emergency transport systems and hospital collaboration when transferring need to be addressed. In this study, the clinical outcomes of endovascular thrombectomy for transferred patients were analyzed.
Methods: Acute ischemic stroke patients who underwent endovascular thrombectomy between January 2016 and March 2019 were enrolled. They were retrospectively reviewed and divided into the direct group and transfer group, and we compared treatment results and clinical outcomes between them.
Results: In all, 122 patients met the inclusion criteria, comprising 93 patients in the direct group and 29 patients in the transfer group. The time from onset to door of our hospital was longer in the transfer group than in the direct group (73 minutes vs. 158 minutes, P = 0.80), but the time from arrival to reperfusion was significantly shorter in the transfer group (139 minutes vs. 106 minutes, P = 0.001). As the time from onset to reperfusion did not differ significantly between the two groups (220 minutes vs. 256 minutes, P = 0.60), there was no significant difference in good outcome at discharge (38.7 vs. 41.3%, P = 0.79).
Conclusion: Clinical outcomes of transferred patients for endovascular thrombectomy may be equivalent to those of directly transported patients. Promoting close hospital cooperation may improve clinical outcomes and resolve regional disparities.
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http://dx.doi.org/10.5797/jnet.oa.2019-0098 | DOI Listing |
Ann Intern Med
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Durham VA Health Care System, Durham; and Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, North Carolina (K.M.G.).
Background: Tissue-based genomic classifiers (GCs) have been developed to improve prostate cancer (PCa) risk assessment and treatment recommendations.
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Data Sources: MEDLINE, EMBASE, and Web of Science published from January 2010 to August 2024.
J Med Internet Res
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Department of Basic and Community Nursing, School of Nursing, Nanjing Medical University, NanJing, China.
Background: Telehealth interventions can effectively support caregivers of people with dementia by providing care and improving their health outcomes. However, to successfully translate research into clinical practice, the content and details of the interventions must be sufficiently reported in published papers.
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J Med Internet Res
January 2025
AIMS Lab, Center for Neurosciences, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.
Background: Cognitive deterioration is common in multiple sclerosis (MS) and requires regular follow-up. Currently, cognitive status is measured in clinical practice using paper-and-pencil tests, which are both time-consuming and costly. Remote monitoring of cognitive status could offer a solution because previous studies on telemedicine tools have proved its feasibility and acceptance among people with MS.
View Article and Find Full Text PDFJ Clin Psychiatry
January 2025
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, and Department of Psychiatry, New York University School of Medicine, New York, New York.
There are few established treatments for negative symptoms in schizophrenia, which persist in many patients after positive symptoms are reduced. Oxidative stress, inflammation, and epigenetic modifications involving histone deacetylase (HDAC) have been implicated in the pathophysiology of schizophrenia. Sulforaphane has antioxidant properties and is an HDAC inhibitor.
View Article and Find Full Text PDFJ Clin Psychiatry
January 2025
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York.
To provide proof-of-concept (PoC), dose-range finding, and safety data for BI 1358894, a TRPC4/5 ion channel inhibitor, in patients with borderline personality disorder (BPD). This was a phase 2, multinational, randomized, double-blind, placebo controlled trial. Patients were randomized to oral placebo or BI 1358894 (5 mg, 25 mg, 75 mg, or 125 mg) once daily in a 2.
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