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http://dx.doi.org/10.1038/s43018-023-00603-1 | DOI Listing |
Nat Cancer
September 2023
Breast Oncology Program, Dana-Farber Cancer Institute, Boston, MA, USA.
Trends Pharmacol Sci
May 2009
Department of Chemical Physiology, The Scripps Research Institute, La Jolla CA 92037, USA.
The sialic-acid-binding immunoglobulin-like lectins (siglecs) comprise a family of receptors that are differentially expressed on leukocytes and other immune cells. The restricted expression of several siglecs to one or a few cell types makes them attractive targets for cell-directed therapies. The anti-CD33 (also known as Siglec-3) antibody gemtuzumab (Mylotarg) is approved for the treatment of acute myeloid leukemia, and antibodies targeting CD22 (Siglec-2) are currently in clinical trials for treatment of B cell non-Hodgkins lymphomas and autoimmune diseases.
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