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Pathogenic variants in and genes associated with female breast and ovarian cancer in the Mexican population.
J Med Life
January 2025
Department of Chemical-Biological Sciences, Autonomous University of Ciudad Juarez, Ciudad Juarez, Chihuahua, Mexico.
Breast and ovarian cancers are significant global health challenges, with inherited variations in breast cancer gene 1 () and breast cancer gene 2 () substantially increasing the risk, aggressiveness, and early onset of these diseases. This work aimed to examine pathogenic variants (PVs) in and databases that include Mexican populations. A systematic review of literature and data mining spanning from 2002 to 2023 was conducted.
View Article and Find Full Text PDFA geranylgeranyl reductase homolog required for cholesterol production in Myxococcota.
J Bacteriol
March 2025
Department of Earth Systems Science, Stanford University, Stanford, California, USA.
Unlabelled: Myxococcota is a phylum of sterol-producing bacteria. They exhibit a clade depth for sterol biosynthesis unparalleled in the bacterial domain and produce sterols of a biosynthetic complexity that rivals eukaryotes. Additionally, the sterol biosynthesis pathways found in this phylum have been proposed as a potential source for sterol biosynthesis in the last eukaryotic common ancestor, lending evolutionary importance to our understanding of this pathway in Myxococcota.
View Article and Find Full Text PDFPhyloformer: Fast, accurate and versatile phylogenetic reconstruction with deep neural networks.
Mol Biol Evol
March 2025
Laboratory of Computational and Quantitative Biology, Paris, France.
Phylogenetic inference aims at reconstructing the tree describing the evolution of a set of sequences descending from a common ancestor. The high computational cost of state-of-the-art maximum likelihood and Bayesian inference methods limits their usability under realistic evolutionary models. Harnessing recent advances in likelihood-free inference and geometric deep learning, we introduce Phyloformer, a fast and accurate method for evolutionary distance estimation and phylogenetic reconstruction.
View Article and Find Full Text PDFMitogenomic phylogeny and divergence time estimation of Artemia Leach, 1819 (Branchiopoda: Anostraca) with emphasis on parthenogenetic lineages.
BMC Genomics
March 2025
Departamento de Ciencias Biológicas y Biodiversidad, Universidad de Los Lagos, Osorno, 5290000, Chile.
The brine shrimp Artemia, a crustacean adapted to the extreme conditions of hypersaline environments, comprises nine regionally distributed sexual species scattered (island-like) over heterogeneous environments and asexual (parthenogenetic) lineages with different ploidies. Such sexual and asexual interaction within the genus raises questions regarding the origin and time of divergence of both sexual species and asexual lineages, including the persistence of the latter over time, a problem not yet clarified using single mitochondrial and nuclear markers. Based on the complete mitochondrial genome of all species and parthenogenetic lineages, this article first describes the mitogenomic characteristics (nucleotide compositions, genome mapping, codon usage, and tRNA secondary structure) of sexual species and asexual types and, secondly, it provides a comprehensive updated phylogenetic analysis.
View Article and Find Full Text PDFReciprocal regulation between Acinetobacter baumannii and Enterobacter cloacae AdeR homologs: implications for antimicrobial resistance and pathogenesis.
PLoS One
March 2025
Departament de Genètica i de Microbiologia, Facultat de Biociènces, Universitat Autònoma de Barcelona (UAB) Campus Bellaterra, Barcelona, Spain.
Acinetobacter baumannii and Enterobacter cloacae are phylogenetically distant Gram-negative bacterial pathogens that represent significant challenges in healthcare settings due to their remarkable ability to acquire antimicrobial resistance. This study investigates one of the most important efflux pump systems in A. baumannii, AdeABC-AdeRS, and identifies homologous components in E.
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