Kuwanons A () and B () are two natural prenylated flavones isolated from the root bark of L. In this study, the first total syntheses of kuwanons A () and B () were achieved from a common intermediate with overall yields of 6.6% and 11.6%, respectively. Kuwanon B () exhibited antibacterial activity against Gram-positive bacteria and concentration-dependent bactericidal activity against bacteria. Preliminary mechanism of action studies suggested that this compound killed bacteria rapidly by disrupting bacterial membrane integrity.
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| http://dx.doi.org/10.1021/acs.jnatprod.3c00466 | DOI Listing |
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