Efficacy of Silkworm Pupae Extract on Muscle Strength and Mass in Middle-Aged and Older Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial.

J Nutr Health Aging

Sang Yeoup Lee, Family Medicine Clinic, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea, Telephone: +82-55-390-1442, E-mail: Fax: +82-51-510-8125.

Published: July 2023

Objectives: We investigated the efficacy and safety of silkworm pupae extract (SWP) consumption for 12 weeks on muscle mass and strength in middle-aged and older individuals with relatively low skeletal muscle mass who do regular low-intensity exercise.

Design: A randomized double-blinded placebo-controlled trial.

Participants: The study was conducted with 54 participants with relatively low skeletal muscle mass (SMM) (64.4 ± 6.1 years; body mass index, 23.8 ± 2.4 kg/m2).

Intervention And Measurements: Participants were randomly assigned to one of two groups: 1000 mg of SWP/day plus regular exercise (SWP group, n=27) or placebo plus regular exercise (placebo group, n=27). All participants were required to engage in 30-60 minutes/day of walking for ≥3 days/week for 12 weeks. The primary outcome was knee extension/flexion strength (Nm), measured at the velocity of 60°/s. Secondary outcomes included body composition, biomarkers (creatine kinase and creatinine), handgrip strength, and quality of life questionnaire.

Results: Both the intention-to-treat (ITT) and per-protocol (PP) analyses revealed no significant impact of SWP on knee strength compared to the placebo group over 12 weeks. On the other hand, the SWP group had significantly greater increases in right-handgrip strength by 1.94 kg (95% CI: 0.08-3.79; p = 0.041) and left-handgrip strength by 1.83 kg (0.25-3.41; p = 0.024) compared to the placebo group in the ITT population, after 12 weeks. Moreover, in the PP population, the SWP group revealed an even greater increase in right-handgrip strength by 2.07 kg (0.15-3. 98; p = 0.035) and left-handgrip strength by 2.21 kg (0.60-3.83; p = 0.008) for the 12-week period. However, this study resulted in a failure to detect significant differences in the body composition, biomarkers, quality of life questionnaire, physical activity, and caloric intake between the groups. None of the participants in the SWP group experienced any significant adverse events. In the placebo group, two participants experienced urticaria and allergic side effects, leading to their withdrawal from the study and two exhibited elevated levels of liver enzyme and increased diastolic blood pressure, respectively at 12 weeks.

Conclusion: SWP, in addition to low-intensity exercise, may enhance handgrip strengths in middle-aged and older adults with relatively lower SMM. Future studies need to use a large sample size over longer periods to validate our findings. This trial was registered at clinicaltrials.gov as NCT04994054.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12603-023-1942-9DOI Listing

Publication Analysis

Top Keywords

swp group
16
placebo group
16
middle-aged older
12
muscle mass
12
strength
9
silkworm pupae
8
pupae extract
8
older individuals
8
low skeletal
8
skeletal muscle
8

Similar Publications

Association of Opioid Use Disorder-Related Service Trajectories during Pregnancy and Postpartum Health Service Use: A Group-Based Multitrajectory Modeling Study.

J Addict Med

December 2024

From the Department of Psychology, University of Notre Dame, Notre Dame, IN (YF); School of Nursing, Vanderbilt University, Nashville, TN (ADJ, JCP); Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN (ADJ); Department of Health Policy, Vanderbilt University School of Medicine, Nashville, TN (GMH, AAL); Department of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, GA (SWP); Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA (SWP); Health Services Research Center, Emory University School of Medicine, Emory University, Atlanta, GA (SWP); Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN (JY, SO); and Massachusetts General Hospital and Harvard Medical School, Boston MA (ER).

Objective: The aim of the study was to examine the relationship between opioid use disorder (OUD)-related service trajectories during pregnancy and postpartum emergency department (ED) and hospitalizations.

Methods: We used the Merative MarketScan Commercial Claims and Encounters Database (2013-2021) to identify a cohort of pregnant individuals with OUD. We used group-based multitrajectory modeling to identify opioid-related treatment and service trajectories during pregnancy and examined their association with postpartum ED and hospital utilization.

View Article and Find Full Text PDF

Background: Pulmonary vein isolation (PVI) alone is less effective in patients with persistent atrial fibrillation (AF) compared with those with paroxysmal AF. We investigate whether additional linear ablation from the superior vena cava to the right atrial septum and cavotricuspid isthmus ablation improves the rhythm outcome of patients with persistent AF undergoing cryoballoon PVI (Cryo-PVI).

Methods: In this investigator-initiated, multicenter, randomized clinical trial, 289 patients with persistent AF refractory to antiarrhythmic drug therapy were randomized 1:1 to either Cryo-PVI with additional right atrium (RA) linear ablation or Cryo-PVI alone.

View Article and Find Full Text PDF

Background: This report summarizes the 2023 inaugural annual meeting of the Cystic Fibrosis Foundation's Prioritizing Research in Mental Health (PRIME) working group. This workshop focused on mental health and elexacaftor/tezacaftor/ivacaftor (ETI).

Methods: We reviewed existing literature and identified key gaps and study design considerations in preclinical work, pharmacokinetics/pharmacodynamics, mood/anxiety, quality of life/self-perception, neuropsychological symptoms, sleep, and symptom management.

View Article and Find Full Text PDF
Article Synopsis
  • The study examined how different diets for European seabass affect the composition of their faeces, particularly focusing on the nutrients that remain undigested and the potential for those faeces to produce organic acids through anaerobic digestion.
  • Researchers tested faecal samples from six different diets in anoxic conditions to analyze nutrient solubilization and the yield of organic acids over a 14-day period.
  • Findings indicated that faeces with higher protein relative to carbohydrates produced more organic acids, especially acetate, while the overall bacterial diversity in the faeces remained similar despite some variations in specific genera.
View Article and Find Full Text PDF

A substantial amount of process waste is generated during the manufacture of soft-wheat products (SWPs), such as biscuits/cookies, crackers, wafers, and cakes. A small portion of waste is reused in specific biscuits, whereas the rest is usually discarded. This study aimed to investigate the suitability of this waste for the co-production of bioethanol and fatty acid methyl esters (FAMEs or biodiesel).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!