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Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin. | LitMetric

Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin.

Front Endocrinol (Lausanne)

Clinical Biochemistry Service, Virgen Macarena University Hospital and Department of Medical Biochemistry and Molecular Biology and Immunology, School of Medicine, University of Seville, Seville, Spain.

Published: August 2023

AI Article Synopsis

  • Gestational diabetes mellitus (GDM) can lead to macrosomia (large fetuses) due to altered nutrient transport in the placenta, with leptin being a key hormone involved in this process.
  • Recent research shows that leptin levels increase in placentas affected by GDM, but its specific effects on nutrient transport (like glucose and amino acids) are not fully understood.
  • Understanding how leptin regulates placental transport could help develop new strategies to improve maternal health and normalize fetal growth in cases of both undergrowth and overgrowth.

Article Abstract

Gestational diabetes mellitus (GDM) is the most frequent pathophysiological state of pregnancy, which in many cases produces fetuses with macrosomia, requiring increased nutrient transport in the placenta. Recent studies by our group have demonstrated that leptin is a key hormone in placental physiology, and its expression is increased in placentas affected by GDM. However, the effect of leptin on placental nutrient transport, such as transport of glucose, amino acids, and lipids, is not fully understood. Thus, we aimed to review literature on the leptin effect involved in placental nutrient transport as well as activated leptin signaling pathways involved in the expression of placental transporters, which may contribute to an increase in placental nutrient transport in human pregnancies complicated by GDM. Leptin appears to be a relevant key hormone that regulates placental transport, and this regulation is altered in pathophysiological conditions such as gestational diabetes. Adaptations in the placental capacity to transport glucose, amino acids, and lipids may underlie both under- or overgrowth of the fetus when maternal nutrient and hormone levels are altered due to changes in maternal nutrition or metabolic disease. Implementing new strategies to modulate placental transport may improve maternal health and prove effective in normalizing fetal growth in cases of intrauterine growth restriction and fetal overgrowth. However, further studies are needed to confirm this hypothesis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10366688PMC
http://dx.doi.org/10.3389/fendo.2023.1172831DOI Listing

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