A gas hypoxic mixture containing 10 percent of O2 and 90 percent of N2 was shown to exert a radioprotective action on pregnant rats and young rats of the first generation if animals were exposed to ionizing radiation during the periods of preimplantation, organogenesis and fetus development. The effect depended on the radiation dose and the period of the intrauterine development of fetus.
Download full-text PDF |
Source |
---|
Molecules
December 2024
Department of Inorganic & Analytical Chemistry, Faculty of Science & Technology, University of Debrecen, H-4032 Debrecen, Hungary.
Heterobimetallic complexes of an ambidentate deferiprone derivative, 3-hydroxy-2-methyl-1-(3-((pyridin-2-ylmethyl)amino)propyl)pyridin-4(1H)-one (PyPropHpH), incorporating an octahedral [Co(4N)] (4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa)) and a half-sandwich type [(η--cym)Ru] (-cym = -cymene) entity have been synthesized and characterized by various analytical techniques. The reaction between PyPropHpH and [Co(4N)Cl]Cl resulted in the exclusive (O,O) coordination of the ligand to Co(III) yielding [Co(tren)PyPropHp](PF) () and [Co(tpa)PyPropHp](PF) (). This binding mode was further supported by the molecular structure of [Co(tpa)PyPropHp](ClO)(OH)·6HO () and [Co(tren)PyPropHpH]Cl(PF)·2HO·CHOH (), respectively, obtained via the slow evaporation of the appropriate reaction mixtures and analyzed using X-ray crystallography.
View Article and Find Full Text PDFAesthetic Plast Surg
January 2025
Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No. 15, Changle West Road, Xi'an, 710032, Shaanxi, China.
Background And Objective: Adipose-derived mesenchymal stem cell-derived extracellular vesicles (ASCs-Exos) possess angiogenic potential, which can enhance the retention rate of fat grafts. Hypoxic preconditioning can augment their functionality. However, the optimal conditions for hypoxic preconditioning and the specific mechanisms by which it exerts its effects are not well defined.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
December 2024
Department of Ophthalmology, Aarhus University Hospital, Aarhus, Denmark.
Purpose: Previous in vitro studies on porcine retinal arterioles have shown that the frequency and amplitude of retinal vasomotion can be affected by hypoxia and nitric oxide (NO). However, it is unknown whether these effects can be reproduced in humans in vivo.
Methods: Video recordings of retinal arterioles from 40 healthy subjects were studied before and during breathing of a hypoxic gas mixture consisting of 12.
The noble gas argon is one of the most promising neuroprotective agents for hypoxic-reperfusion injuries of the brain. However, its effect on traumatic injuries has been insufficiently studied. The aim of this study was to analyze the effect of the triple inhalation of the argon-oxygen mixture Ar 70%/O 30% on physical and neurological recovery and the degree of brain damage after traumatic brain injury and to investigate the possible molecular mechanisms of the neuroprotective effect.
View Article and Find Full Text PDFJ Clin Monit Comput
December 2024
Pediatric perioperative medicine and Intensive Care, Karolinska University Hospital, Eugeniavägen 23, Stockholm, 171 64, Sweden.
Purpose: The capnodynamic method, End Expiratory Lung Volume CO (EELV-CO), utilizes exhaled carbon dioxide analysis to estimate End-Expiratory Lung Volume (EELV) and has been validated in both normal lungs and lung injury models. Its performance under systemic hypoxia and variations in CO elimination is not examined. This study aims to validate EELV-CO against inert gas wash in/wash out (EELV- SF6, sulfur hexafluoride) in a porcine model of stable hemodynamic conditions followed by hypoxic pulmonary vasoconstriction and inhaled nitric oxide (iNO).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!