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Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine activated by allergens, pathogens, and air pollutants. Recent studies suggest TSLP dysregulation in chronic inflammatory diseases. It was highlighted as a key player in the context of asthma-associated mucosal immunity.
View Article and Find Full Text PDF[Allergy and immunotoxicology in preventive and clinical medicine from theory to practice: Environmental factors in Bronchial Asthma].
Sangyo Eiseigaku Zasshi
November 2024
The committee members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH).
Background: According to the gene-environment interactions (GEi) concept, the mechanism of health impairment can be explained by genetic factors, environmental factors, or their interaction. Physical and mental health effects resulting from environmental exposure may be classified either as toxicity, immune response, and allergic reaction. Moreover, despite the already established therapeutic approaches to bronchial asthma and decreasing mortality due to bronchial asthma, patients with difficult and severe asthma are increasing in number.
View Article and Find Full Text PDFTemporal variation in the effectiveness of biologics in asthma: Effect modification by changing patient characteristics.
Respir Med
November 2024
Division of Allergy and Clinical Immunology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address:
Background: The underlying population of patients selected for each respiratory monoclonal antibody might change as other biologics are approved.
Objective: To evaluate effect modification by calendar time of the effectiveness of each respiratory biologics in asthma.
Methods: The Effectiveness of Respiratory biologics in Asthma (ERA) is a retrospective cohort of severe asthma patients from the Mass General Brigham clinics between January 2013 and September 2023.
Anti-alarmin asthma therapies: where do we go from here?
J Bras Pneumol
July 2023
. Faculty of Health Sciences, McMaster University, Hamilton (ON) Canada.
The Role of Airway Epithelial Cell Alarmins in Asthma.
Cells
March 2022
Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
The airway epithelium is the first line of defense for the lungs, detecting inhaled environmental threats through pattern recognition receptors expressed transmembrane or intracellularly. Activation of pattern recognition receptors triggers the release of alarmin cytokines IL-25, IL-33, and TSLP. These alarmins are important mediators of inflammation, with receptors widely expressed in structural cells as well as innate and adaptive immune cells.
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