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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10363496 | PMC |
| http://dx.doi.org/10.1016/j.lansea.2023.100211 | DOI Listing |
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Investigating the Relationship Between Anti-seizure Medications and Bleeding Disorders: A Comprehensive Review of the Current Literature.
Drugs Real World Outcomes
January 2025
Kabul University of Medical Sciences, Kabul, Afghanistan.
Anti-seizure medications (ASMs) are specific types of anticonvulsants used to treat epileptic seizures. However, several studies have shown an association between ASMs and an increased risk of hematological disorders, such as thrombocytopenia, aplastic anemia, and platelet function disorders leading to prolonged bleeding times. This review explores the existing literature on this topic, investigating a wide variety of ASMs, ranging from first-generation medications to newer ones.
View Article and Find Full Text PDFSeizure aggravation by ampicillin/sulbactam in an elderly patient with status epilepticus.
Int J Emerg Med
January 2025
Department of Neurology, Tenri Hospital, Tenri, Nara, Japan.
Background: Ampicillin/sulbactam (ABPC/ SBT) is one of the most common β-lactam antibiotics for patients with status epilepticus complicated with aspiration pneumonia. It is known that β-lactam antibiotics such as penicillin aggravate epileptic seizures or status epilepticus. Here, we investigated whether ABPC/SBT aggravates seizures using electroencephalography (EEG) monitoring.
View Article and Find Full Text PDFBrain calcification in congenital heart defects and ectodermal dysplasia (CHDED).
Eur J Med Genet
December 2024
Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan. Electronic address:
Article Synopsis
- CHDED (Congenital Heart Defect and Ectodermal Dysplasia) is an autosomal dominant disorder linked to the PRKD1 gene, characterized by heart issues and ectodermal abnormalities.
- A case study of a 9-month-old Japanese girl demonstrated brain calcifications and seizures, revealing a new pathogenic variant in the PRKD1 gene.
- It is suggested that PRKD1, along with ITGB2 and JAM2, may interact through a common signaling pathway leading to brain calcifications, providing insight into the genetic basis of this disorder.
Late-Onset Idiopathic Generalized Epilepsy Manifesting With De Novo Late-Onset Absence Status Epilepticus After COVID-19 Infection: A Case Report.
Cureus
November 2024
Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN.
Herein, we present a case of idiopathic generalized epilepsy (IGE) manifesting as de novo late-onset absence status epilepticus (ASE) following mild coronavirus disease 2019 (COVID-19). A woman in her 40s presented with persistent 3-5.5 Hz generalized spike-wave complexes (SWCs) on electroencephalography (EEG).
View Article and Find Full Text PDFBilateral Reversible Corneal Edema as a Novel Side-Effect of Levetiracetam - A Case Report.
Int Med Case Rep J
December 2024
Department of Ophthalmology, Mater Dei Hospital, Imsida, MSD, 2090, Malta.
Purpose: We present a case of levetiracetam-induced corneal edema. To the best of our knowledge, this is the first documented case of bilateral reversible corneal edema secondary to levetiracetam use.
Patients And Methods: A 59-year-old woman was referred to the ophthalmology department with a few weeks' history of bilateral blurring of vision.
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