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Anticholinergic Versus Antihistaminic Treatment for Simulator Sickness Prevention. | LitMetric

AI Article Synopsis

  • Flight simulators are vital for training aircrew, but they can sometimes induce simulator sickness, which resembles motion sickness.
  • This study aimed to evaluate the effectiveness of two medications, scopolamine (an anticholinergic) and cinnarizine (an antihistamine), in preventing simulator sickness among helicopter pilots.
  • Results showed that cinnarizine significantly reduced simulator sickness symptoms, whereas scopolamine was less effective, leading to a recommendation for cinnarizine as a preferable treatment option.

Article Abstract

Flight simulators have an essential role in aircrew training. Occasionally, symptoms of motion sickness, defined as simulator sickness, develop during these sessions. Preventive methods for motion sickness have been investigated thoroughly; however, only a few studies have examined preventive treatments for simulator sickness. The aim of this study was to examine the efficacy of scopolamine (an anticholinergic drug) compared with cinnarizine (an antihistaminic drug) for helicopter simulator sickness prevention. A validated simulator sickness questionnaire (SSQ) score was used to determine the severity of simulator sickness symptoms in this study. Preliminary SSQ scores and SSQ scores after each sortie were calculated. Each participant was given scopolamine, cinnarizine, or a placebo in a double-blind randomized manner before the first sortie of each training day. Forty-one helicopter pilots participated in the trial. The average age was 30.5 ± 7.1 years. SSQ values significantly improved from an average of 73.30 in the preliminary SSQ questionnaire to an average of 30.92 after 2 hours following the administration of cinnarizine (P = .012, 95%CI 8.071-76.703). Scopolamine was found to be less effective than both cinnarizine and the placebo in the alleviation of simulator sickness symptoms. This study is the first to compare scopolamine with cinnarizine for simulator sickness prevention. Based on the results of this study, we recommend the use of cinnarizine over scopolamine for simulator sickness prevention.

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Source
http://dx.doi.org/10.1002/jcph.2319DOI Listing

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