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Pathways to One Health: Enhancing Inter-Sectoral Collaboration in Pakistan.
Ecohealth
January 2025
Health Services Academy, Chak Shahzad, Park Road, Islamabad, 44000, Pakistan.
One Health is an integrative approach aiming to achieve optimal health outcomes by recognizing the interconnection between humans, animals, and the environment. This study explores the understanding, perspectives, hurdles, and implications of intersectoral collaboration within Pakistan's human health system, focusing on One Health principles. A qualitative phenomenological approach was employed, involving 17 key informant interviews with purposively selected stakeholders from public health, agriculture, veterinary medicine, agriculture and environmental science.
View Article and Find Full Text PDFAdvances in Heavy Metal Sensing: Utilizing Immobilized Chromogenic Reagents, Nanomaterials Perovskite and Nanonzymes.
Crit Rev Anal Chem
January 2025
Department of Chemistry, University of Delhi, New Delhi, India.
Heavy metal pollution is a major environmental and health problem due to the toxicity and persistence of metals such as lead, mercury, cadmium, and arsenic in water, soil, and air. Advances in sensor technology have significantly improved the detection and quantification of heavy metals, providing real-time monitoring and mitigation tools. This review explores recent developments in heavy metal detection, focusing on innovative uses of immobilized chromogenic reagents, nanomaterials, perovskites, and nanozymes.
View Article and Find Full Text PDFNegotiating a physically active life in tune with ageing: a grounded theory study of older persons' experiences of participating in high-intensity interval training.
BMC Geriatr
January 2025
Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Background: Physical activity and exercise are promoted worldwide as effective interventions for healthy ageing. Various exercise initiatives have been developed and evaluated for their efficacy and effectiveness among older populations. However, a deeper understanding of participants' experiences with these initiatives is crucial to foster long-term activity and exercise among older persons.
View Article and Find Full Text PDFA cross-tissue transcriptome-wide association study identifies new key genes in ischemic stroke.
Gene
January 2025
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China; Department of Neurology, Fujian Provincial Hospital, Fuzhou, Fujian, China; Fujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou, Fujian, China. Electronic address:
Background: Ischemic stroke (IS) is an important disease causing death and disability worldwide, and further investigation of IS-related genes through genome-wide association study (GWAS) data is valuable.
Methods: The study included GWAS data from 62,100 IS patients of European origin and 1,234,808 controls in a cross-tissue transcriptome association study (TWAS). A joint analysis was first performed by the Unified Test for Molecular Markers (UTMOST) and FUSION methods.
Targeted mitochondrial function for cardiac fibrosis: An epigenetic perspective.
Free Radic Biol Med
January 2025
Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, PR China; Center for Scientific Research and Experiment, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, PR China. Electronic address:
Mitochondria, commonly referred to as "energy factories"of cells, play a crucial role in the function and survival of cardiomyocytes. However, as research on cardiac fibrosis has advanced, mitochondrial dysfunction(including changes in energy metabolism, calcium ion imbalance, increased oxidative stress, and apoptosis)is now recognized as a significant pathophysiological pathway involved in cardiac remodeling and progression, which also negatively affects the function and structure of the heart. In recent years, research focusing on targeting mitochondria has gained significant attention, offering new approaches for treating cardiac fibrosis.
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