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Enhancing the quality of inferior oocytes of buffalo for in vitro embryo production: The impact of melatonin on maturation, SCNT, and epigenetic modifications.
Tissue Cell
August 2024
Animal Physiology and Reproduction Division, ICAR-Central Institute for Research on Buffaloes, Hisar, Haryana 125001, India. Electronic address:
Success of animal cloning is limited by oocyte quality, which is closely linked to reprogramming ability. The number of layers of cumulus cells is typically used to assess the quality of oocyte; a minimum of one-third of collected cumulus-oocyte complexes (COCs) are discarded as inferior oocytes because they have less cumulus cells. Melatonin, which has been recognised for its ability to sequester free radicals and perform multiple functions, has emerged as a potentially effective candidate for enhancing inferior oocytes quality and, consequently, embryo development competency.
View Article and Find Full Text PDFIncidence and risk factors associated with surgical site infection in acetabular fracture patients: An experience from north India.
J Clin Orthop Trauma
May 2024
Department of Orthopaedic Surgery, King George's Medical University, Shah Mina Rd, Chowk, Lucknow, Uttar Pradesh, 226003, India.
Introduction: Nearly 5-7% of patients undergoing surgical management of acetabular fractures develop surgical site infection (SSI) which is one of the most important factors affecting the hospital stay, success of procedure and overall patient satisfaction. Systematic studies to identify the risk factors and their control could help to reduce the surgical site infection rate considerably. The present study assessed the incidence and risk factors related with SSI in patients undergoing surgical management of acetabular fractures at our center.
View Article and Find Full Text PDFStudy of the Practice of Surgical Antibiotic Prophylaxis Use for Elective Neurosurgical Cases in a Tertiary Hospital and Understanding the Rationale.
World Neurosurg
September 2024
Department of Medicine, University Malaya, Kuala Lumpur, Malaysia.
Article Synopsis
- - The study investigates how well surgical antibiotic prophylaxis (SAP) guidelines are followed in elective neurosurgery at a Malaysian teaching hospital and its effect on surgical site infection (SSI) rates.
- - A review of 202 patients showed 99% compliance with antibiotic choice but only 69.8% with the recommended duration, with an SSI rate of 6.4%.
- - Although surgeons are generally knowledgeable about SAP guidelines, inconsistencies in practice indicate the need for improved education and auditing to enhance patient outcomes and reduce SSI rates.
To Study the Efficacy and Safety of Diosmin with Tranexamic Acid and Mefenamic Acid Versus only Tranexamic Acid and Mefenamic Acid in Medical Management of Abnormal Uterine Bleeding: A Randomized Controlled Trial.
J Midlife Health
September 2023
Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India.
Article Synopsis
- Abnormal uterine bleeding (AUB) is prevalent in women of reproductive and perimenopausal ages and is often treated with medications like mefenamic acid and tranexamic acid, either alone or in combination with hormonal treatments.
- A recent study tested the effectiveness of adding diosmin to the standard treatment of tranexamic acid and mefenamic acid in reducing menstrual blood loss, involving 184 participants randomly assigned to two groups.
- Results showed that both treatments significantly reduced bleeding days and blood loss, with the group receiving diosmin experiencing greater improvements in both these areas and in hemoglobin levels post-treatment.
Comprehensive insight into the molecular interaction of rutin with human transferrin: Implication of natural compounds in neurodegenerative diseases.
Int J Biol Macromol
December 2023
Gachon Institute of Pharmaceutical Science and Department of Pharmacy, College of Pharmacy, Gachon University, Incheon, Republic of Korea. Electronic address:
Neurodegeneration, a process of irreversible neuronal damage, is characterized by a damaged neuronal structure and function. The interplay between various proteins maintains homeostasis of essential metals in the brain, shielding neurons from degeneration; human transferrin (Htf) is essential in maintaining iron homeostasis. Any disruption in iron homeostasis results in the development of neurodegenerative diseases (NDs) and their pathology, mainly Alzheimer's disease (AD).
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