Increased invasive bloodstream infections caused by multidrug resistant Shigella sonnei were noted in Vancouver, British Columbia, Canada, during 2021-2023. Whole-genome sequencing revealed clonal transmission of genotype 3.6.1.1.2 (CipR.MSM5) among persons experiencing homelessness. Improvements in identifying Shigella species, expanding treatment options for multidrug resistant infections, and developing public health partnerships are needed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370870PMC
http://dx.doi.org/10.3201/eid2908.230323DOI Listing

Publication Analysis

Top Keywords

shigella sonnei
8
persons experiencing
8
experiencing homelessness
8
vancouver british
8
british columbia
8
columbia canada
8
multidrug resistant
8
multidrug-resistant shigella
4
sonnei bacteremia
4
bacteremia persons
4

Similar Publications

Dysentery caused by Shigella species remains a major health threat to children in low- and middle-income countries. There is no vaccine available. The most advanced candidates, i.

View Article and Find Full Text PDF

(Gaertn) Roxb. and Retz. are significant botanicals in ancient Ayurvedic medicine.

View Article and Find Full Text PDF

Unlabelled: Toxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division. TA systems have also been implicated in bacterial persistence and antibiotic tolerance, which can be precursors of antibiotic resistance. Here, we identified a clinical isolate of (CS14) with a remarkably stable pINV virulence plasmid; pINV is usually frequently lost from , but plasmid loss was not detected from CS14.

View Article and Find Full Text PDF

infection poses a significant public health challenge in the developing world. However, lack of a widely available mouse model that replicates human shigellosis creates a major bottleneck to better understanding of disease pathogenesis and development of newer drugs and vaccines. BALB/c mice pre-treated with streptomycin and iron (FeCl) plus desferrioxamine intraperitoneally followed by oral infection with virulent resulted in diarrhea, loss of body weight, bacterial colonization and progressive colitis characterized by disruption of epithelial lining, loss of crypt architecture with goblet cell depletion, increased polymorphonuclear infiltration into the mucosa, submucosal swelling (edema), and raised proinflammatory cytokines and chemokines in the large intestine.

View Article and Find Full Text PDF

Cluster of extensively drug-resistant Shigella sonnei carrying bla in Los Angeles, California, 2023 to 2024.

Am J Infect Control

December 2024

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA. Electronic address:

We describe 3 cases of extensively drug-resistant Shigella sonnei infections among men who have sex with men in Los Angeles, CA. Using whole-genome sequencing, we determined that they are highly genetically related, exhibit similar antimicrobial resistomes, and appear to be distinct from other circulating strains. These cases highlight the rapid expansion of extensively drug-resistant Shigella in the United States and the urgent need for appropriate detection and management.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!