[This retracts the article DOI: 10.3389/fphar.2018.00556.].

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361746PMC
http://dx.doi.org/10.3389/fphar.2023.1252194DOI Listing

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Article Synopsis
  • * The study found that the lipopolysaccharide (LPS) treatment, which normally promotes M1 polarization, actually increases endogenous MLT secretion in macrophages, indicating a possible protective mechanism.
  • * Results show that LPS activates the TLR4/TRIF pathway leading to MLT secretion, with MLT helping to inhibit M1 polarization and reduce apoptosis in macrophages, highlighting its role in immune response and pathogen clearance.
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